学科主题基础医学
Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappa B pathways and promotes cell survival in human cancer cells
Li, Qi; Wang, Lanlan; Tan, Weifeng; Peng, Zhi; Luo, Yang; Zhang, Yingmei; Zhang, Guoying; Na, Daxiang; Jin, Peng; Shi, Taiping; Ma, Dalong; Wang, Lu1
关键词CTRP4 NF-kappa B IL6/STAT3 Cancer related inflammation Cancer therapy
刊名CANCER LETTERS
2011-09-28
DOI10.1016/j.canlet.2011.05.005
308期:2页:203-214
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ULCERATIVE-COLITIS ; COLORECTAL-CANCER ; EPITHELIAL-CELLS ; GASTRIC-CANCER ; ADIPOSE-TISSUE ; LIVER-CANCER ; INTERLEUKIN-6 ; INFLAMMATION ; ACTIVATION ; GROWTH
英文摘要

The NF-kappa B and IL6/STAT3 pathways are major participants in tumor-promoting inflammation. C1qTNF related protein (CTRP) is a family with multiple physiological functions, but their involvement in tumor-promoting inflammation has received little attention. For the first time, we have identified CTRP4 as a novel secretary protein by N-terminal sequencing. Moreover, recombinant CTRP4 can effectively induce the activation of both NF-kappa B and IL6/STAT3 signaling pathways in the pattern similar to that of classical cytokine. By western blot analysis, we detected the upregulation of CTRP4 in response to IL6. Importantly, functional research revealed that CTRP4 could promote tumor cell survival and tumor resistance against apoptosis induced by chemotherapeutics. These results strongly suggest that CTRP4 is a novel tumor-promoting inflammatory regulator. Our findings might provide a meaningful indication for cancer research. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000293153100010
项目编号30971483 ; 2009ZX09503-004 ; 2011ZX09506-005
资助机构National Natural Science Foundation of China ; Program for innovation of new drug
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57129
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学基础医学院
作者单位1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
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GB/T 7714
Li, Qi,Wang, Lanlan,Tan, Weifeng,et al. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappa B pathways and promotes cell survival in human cancer cells[J]. CANCER LETTERS,2011,308(2):203-214.
APA Li, Qi.,Wang, Lanlan.,Tan, Weifeng.,Peng, Zhi.,Luo, Yang.,...&Wang, Lu.(2011).Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappa B pathways and promotes cell survival in human cancer cells.CANCER LETTERS,308(2),203-214.
MLA Li, Qi,et al."Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappa B pathways and promotes cell survival in human cancer cells".CANCER LETTERS 308.2(2011):203-214.
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