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学科主题: 基础医学
题名:
Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappa B pathways and promotes cell survival in human cancer cells
作者: Li, Qi; Wang, Lanlan; Tan, Weifeng; Peng, Zhi; Luo, Yang; Zhang, Yingmei; Zhang, Guoying; Na, Daxiang; Jin, Peng; Shi, Taiping; Ma, Dalong; Wang, Lu1
关键词: CTRP4 ; NF-kappa B ; IL6/STAT3 ; Cancer related inflammation ; Cancer therapy
刊名: CANCER LETTERS
发表日期: 2011-09-28
DOI: 10.1016/j.canlet.2011.05.005
卷: 308, 期:2, 页:203-214
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ULCERATIVE-COLITIS ; COLORECTAL-CANCER ; EPITHELIAL-CELLS ; GASTRIC-CANCER ; ADIPOSE-TISSUE ; LIVER-CANCER ; INTERLEUKIN-6 ; INFLAMMATION ; ACTIVATION ; GROWTH
英文摘要:

The NF-kappa B and IL6/STAT3 pathways are major participants in tumor-promoting inflammation. C1qTNF related protein (CTRP) is a family with multiple physiological functions, but their involvement in tumor-promoting inflammation has received little attention. For the first time, we have identified CTRP4 as a novel secretary protein by N-terminal sequencing. Moreover, recombinant CTRP4 can effectively induce the activation of both NF-kappa B and IL6/STAT3 signaling pathways in the pattern similar to that of classical cytokine. By western blot analysis, we detected the upregulation of CTRP4 in response to IL6. Importantly, functional research revealed that CTRP4 could promote tumor cell survival and tumor resistance against apoptosis induced by chemotherapeutics. These results strongly suggest that CTRP4 is a novel tumor-promoting inflammatory regulator. Our findings might provide a meaningful indication for cancer research. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30971483 ; 2009ZX09503-004 ; 2011ZX09506-005
项目资助者: National Natural Science Foundation of China ; Program for innovation of new drug
WOS记录号: WOS:000293153100010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57129
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China

Recommended Citation:
Li, Qi,Wang, Lanlan,Tan, Weifeng,et al. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappa B pathways and promotes cell survival in human cancer cells[J]. CANCER LETTERS,2011,308(2):203-214.
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