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学科主题: 药学
题名:
Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis
作者: Wang Jiannong1; Jiang Junjie2; Xie Yanming2; Wei Xu2; Li Jianpeng2; Duan Jingli3; Xiong Xin3
关键词: Naringenin ; Pharmacokinetics ; Medicine, Chinese traditional ; Qianggu capsule ; Total flavonoids of Drynaria fortunei
刊名: Journal of Traditional Chinese Medicine
发表日期: 2015-04-15
卷: 35, 期:2, 页:141-153
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; PEDIATRIC-PATIENTS ; PLASMA
英文摘要:

OBJECTIVE: To characterize naringenin (NAR) population pharmacokinetics (PPK) in Chinese women with primary osteoporosis.

METHODS: Ninety-eight female patients with primary osteoporosis from the Jingshan, Beixinqiao, Jiaodaokou, Chaoyangmen, and Donghuamen communities in Beijing, China, aged 40 to 80 years, received oral Qianggu capsules (250 mg). Blood samples were collected before and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, and 24 h after administration. The concentration of NAR in the blood samples was measured using high performance liquid chromatography-tandem mass spectrometry. PPK analyses were performed with nonlinear mixed-effect modeling software (version 7.1.2, PsN3.2.12). The clearance (Cl), central distribution volume (V), absorption rate constant (Ka1), peripheral distribution volume (VII), and inter-compartmental clearance (CLII) were set as parameters and estimated by the base model, covariate model, and final model. Kidney-Yang deficiency [Shenyangxu (SYAX)] and liver-kidney-Yin deficiency (Ganshenyinxu) are patterns of symptoms in Traditional Chinese Medicine that were set as covariates, along with age, height, blood urea nitrogen, serum creatinine, alanine transaminase, aspartate transaminase, and hyperlipidemia. Both step-wise forward and backward procedures were accomplished to build models. The final model was evaluated by internal and external validation, visual predictive check, bootstrap, and leverage analysis.

RESULTS: A one compartment open model with first order degradation was the best fitted to the concentration-time profiles following oral administration of NAR. The mean of population parameters of the final model, Cl, SYAX on C1, V, Ka1, CLII, and VII, Were measured to be 37.6 L/h, 0.427 L, 123 L/h, 0.12/h, 0.3056, and 1.446, respectively. Inter-individual variability was estimated and SYAX was identified as a significant covariate.

CONCLUSION: The population pharmacokinetic model described in this study could effectively characterize the pharmacokinetic profile of NAR following administration of a single dose of oral Qianggu capsules in Chinese women with primary osteoporosis. Among the tested covariates, only SYAX was a significant factor. (C) 2015 JTCM. All rights reserved.

语种: 英语
所属项目编号: 2009ZX09502-030 ; ZZ070834
项目资助者: Significant Drug Research and Development in Important State Science and Technology Specific And Key Technique Research ; China Academy of Chinese Medical Sciences
WOS记录号: WOS:000353367800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57137
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.China Acad Chinese Med Sci, Inst Basic Med Sci, Xi Yuan Hosp, Beijing 100700, Peoples R China
2.China Acad Chinese Med Sci, Chinese Clin Basic Inst, Beijing 100700, Peoples R China
3.Peking Univ, Hosp Affiliated 3, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Wang Jiannong,Jiang Junjie,Xie Yanming,et al. Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis[J]. Journal of Traditional Chinese Medicine,2015,35(2):141-153.
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