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学科主题: 基础医学
题名:
Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain
作者: Liu, Xiao-Dan1,2; Yang, Jing-Jing1; Fang, Dong1; Cai, Jie1,2; Wan, You2; Xing, Guo-Gang1,2,3,4
刊名: PLOS ONE
发表日期: 2014-12-11
DOI: 10.1371/journal.pone.0114623
卷: 9, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ACTION-POTENTIAL ELECTROGENESIS ; NR2B-CONTAINING NMDA RECEPTORS ; PRIMARY AFFERENT NEURONS ; RESISTANT NA+ CURRENT ; NEUROPATHIC PAIN ; INFLAMMATORY PAIN ; SENSORY NEURONS ; DRG NEURONS ; RAT MODEL ; EXPRESSION
英文摘要:

We have previously reported that enhanced excitability of dorsal root ganglia (DRG) neurons contributes to the development of bone cancer pain, which severely decreases the quality of life of cancer patients. Nav1.8, a tetrodotoxin-resistant (TTX-R) sodium channel, contributes most of the sodium current underlying the action potential upstroke and accounts for most of the current in later spikes in a train. We speculate that the Nav1.8 sodium channel is a potential candidate responsible for the enhanced excitability of DRG neurons in rats with bone cancer pain. Here, using electrophysiology, Western blot and behavior assays, we documented that the current density of TTX-R sodium channels, especially the Nav1.8 channel, increased significantly in DRG neurons of rats with cancer-induced bone pain. This increase may be due to an increased expression of Nav1.8 on the membrane of DRG neurons. Accordantly, blockade of Nav1.8 sodium channels by its selective blocker A-803467 significantly alleviated the cancer-induced mechanical allodynia and thermal hyperalgesia in rats. Taken together, these results suggest that functional upregulation of Nav1.8 channels on the membrane of DRG neurons contributes to the development of cancer-induced bone pain.

语种: 英语
所属项目编号: 81371237 ; 31171063 ; 81072951 ; 7112079 ; 201302013-01 ; 2013CB531905
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; special foundation for public welfare profession scientific research program from Ministry of Health of the People&prime ; s Republic of China ; "973" Program of the Ministry of Science and Technology of China
WOS记录号: WOS:000347146700034
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57138
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
3.Minist Hlth, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Neurobiol, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Xiao-Dan,Yang, Jing-Jing,Fang, Dong,et al. Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain[J]. PLOS ONE,2014,9(12).
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