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学科主题: 口腔医学
题名:
Electrospun magnetic poly(L-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles
作者: Shan, Dingying1; Shi, Yuzhou1; Duan, Shun1; Wei, Yan2; Cai, Qing1; Yang, Xiaoping1
关键词: Magnetic nanofibers ; Chemical co-precipitation ; Bone regeneration
刊名: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
发表日期: 2013-08-01
DOI: 10.1016/j.msec.2013.04.040
卷: 33, 期:6, 页:3498-3505
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: BONE-FORMATION ; IN-VIVO ; FIELD ; SCAFFOLDS ; BIOMINERALIZATION
英文摘要:

Magnetic poly(L-lactide) (PLLA)/Fe3O4 composite nanofibers were prepared with the purpose to develop a substrate for bone regeneration. To increase the dispersibility of Fe3O4 nanoparticles (NPs) in the PLLA matrix, a modified chemical co-precipitation method was applied to synthesize Fe3O4 NPs in the presence of PLLA. Trifluoroethanol (TFE) was used as the co-solvent for all the reagents, including Fe(II) and Fe(III) salts, sodium hydroxide, and PLLA The co-precipitated Fe3O4 NPs were surface-coated with PLLA and demonstrated good dispersibility in a PLLA/TFE solution. The composite nanofiber electrospun from the solution displayed a homogeneous distribution of Fe3O4 NPs along the fibers using various contents of Fe3O4 NPs. X-ray diffractometer (XRD) and vibration sample magnetization (VSM) analysis confirmed that the co-precipitation process had minor adverse effects on the crystal structure and saturation magnetization (Ms) of Fe3O4 NPs. The resulting PLLA/Fe3O4 composite nanofibers showed paramagnetic properties with Ms directly related to the Fe3O4 NP concentration. The cytotoxicity of the magnetic composite nanofibers was determined using in vitro culture of osteoblasts (MC3T3-E1) in extracts and co-culture on nanofibrous matrixes. The PLLA/Fe3O4 composite nanofibers did not show significant cytotoxicity in comparison with pure PLLA nanofibers. On the contrary, they demonstrated enhanced effects on cell attachment and proliferation with Fe3O4 NP incorporation. The results suggested that this modified chemical co-precipitation method might be a universal way to produce magnetic biodegradable polyester substrates containing well-dispersed Fe3O4 NPs. This new strategy opens an opportunity to fabricate various kinds of magnetic polymeric substrates for bone tissue regeneration. (c) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012CB933904 ; 2012BAI07B08 ; 51073016 ; 51142004 ; NCET-11-0556
项目资助者: National Basic Research Program of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000320973000051
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57139
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China

Recommended Citation:
Shan, Dingying,Shi, Yuzhou,Duan, Shun,et al. Electrospun magnetic poly(L-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2013,33(6):3498-3505.
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