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Electrospun magnetic poly(L-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles
Shan, Dingying1; Shi, Yuzhou1; Duan, Shun1; Wei, Yan2; Cai, Qing1; Yang, Xiaoping1
关键词Magnetic Nanofibers Chemical Co-precipitation Bone Regeneration
刊名MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
2013-08-01
DOI10.1016/j.msec.2013.04.040
33期:6页:3498-3505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]BONE-FORMATION ; IN-VIVO ; FIELD ; SCAFFOLDS ; BIOMINERALIZATION
英文摘要

Magnetic poly(L-lactide) (PLLA)/Fe3O4 composite nanofibers were prepared with the purpose to develop a substrate for bone regeneration. To increase the dispersibility of Fe3O4 nanoparticles (NPs) in the PLLA matrix, a modified chemical co-precipitation method was applied to synthesize Fe3O4 NPs in the presence of PLLA. Trifluoroethanol (TFE) was used as the co-solvent for all the reagents, including Fe(II) and Fe(III) salts, sodium hydroxide, and PLLA The co-precipitated Fe3O4 NPs were surface-coated with PLLA and demonstrated good dispersibility in a PLLA/TFE solution. The composite nanofiber electrospun from the solution displayed a homogeneous distribution of Fe3O4 NPs along the fibers using various contents of Fe3O4 NPs. X-ray diffractometer (XRD) and vibration sample magnetization (VSM) analysis confirmed that the co-precipitation process had minor adverse effects on the crystal structure and saturation magnetization (Ms) of Fe3O4 NPs. The resulting PLLA/Fe3O4 composite nanofibers showed paramagnetic properties with Ms directly related to the Fe3O4 NP concentration. The cytotoxicity of the magnetic composite nanofibers was determined using in vitro culture of osteoblasts (MC3T3-E1) in extracts and co-culture on nanofibrous matrixes. The PLLA/Fe3O4 composite nanofibers did not show significant cytotoxicity in comparison with pure PLLA nanofibers. On the contrary, they demonstrated enhanced effects on cell attachment and proliferation with Fe3O4 NP incorporation. The results suggested that this modified chemical co-precipitation method might be a universal way to produce magnetic biodegradable polyester substrates containing well-dispersed Fe3O4 NPs. This new strategy opens an opportunity to fabricate various kinds of magnetic polymeric substrates for bone tissue regeneration. (c) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000320973000051
项目编号2012CB933904 ; 2012BAI07B08 ; 51073016 ; 51142004 ; NCET-11-0556
资助机构National Basic Research Program of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57139
专题北京大学口腔医学院_口腔修复科
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
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Shan, Dingying,Shi, Yuzhou,Duan, Shun,et al. Electrospun magnetic poly(L-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2013,33(6):3498-3505.
APA Shan, Dingying,Shi, Yuzhou,Duan, Shun,Wei, Yan,Cai, Qing,&Yang, Xiaoping.(2013).Electrospun magnetic poly(L-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,33(6),3498-3505.
MLA Shan, Dingying,et al."Electrospun magnetic poly(L-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 33.6(2013):3498-3505.
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