北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Decreased dynorphin A(1-17) in the spinal cord of spastic rats after the compressive injury
作者: Dong, HW; Wang, LH; Zhang, M; Han, JS
关键词: dynorphin A (1-17) ; spasticity ; radioimmunoassay (RIA) ; Ashworth score ; H-reflex ; transcutaneous electric nerve stimulation (TENS)
刊名: BRAIN RESEARCH BULLETIN
发表日期: 2005-10-15
DOI: 10.1016/j.brainresbull.2005.06.026
卷: 67, 期:3, 页:189-195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SURFACE ELECTRICAL-STIMULATION ; H-REFLEX ; INTRATHECAL BACLOFEN ; DIFFERENT FREQUENCIES ; NERVE-STIMULATION ; SHORT-TERM ; ELECTROACUPUNCTURE ; IMMUNOREACTIVITY ; TENS
英文摘要:

Spasticity in rat hindlimbs was induced by compressing cervical spinal cord with a wax ball. Ashworth score and H-reflex were measured 1 week after the surgery. The results showed that: (1) muscle spasm was detected in the hindlimbs a week after the operation and maintained at least 8 weeks, (2) in the spastic animals, dynorphin A (1-17)-ir decreased significantly in thoracic and lumbar segments of the spinal cord and (3) peripheral administration Of K receptor agonist U50488H and electrical stimulation at 100 Hz effectively relieved the muscle spasm. Our data supported the note that the reduction of endogenous dynorphin A (1-17) might play an important role in the pathogenesis of spinally induced muscle spasticity and the replenishment of its shortage might relieve the spasticity. (c) 2005 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000232172200004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57142
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Decreased dynorphin A(1-17) in the spinal cord of spastic rats after the compressive injury.pdf(249KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
3.Minist Publ Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Dong, HW,Wang, LH,Zhang, M,et al. Decreased dynorphin A(1-17) in the spinal cord of spastic rats after the compressive injury[J]. BRAIN RESEARCH BULLETIN,2005,67(3):189-195.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dong, HW]'s Articles
[Wang, LH]'s Articles
[Zhang, M]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dong, HW]‘s Articles
[Wang, LH]‘s Articles
[Zhang, M]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace