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学科主题基础医学
Decreased dynorphin A(1-17) in the spinal cord of spastic rats after the compressive injury
Dong, HW; Wang, LH; Zhang, M; Han, JS
关键词dynorphin A (1-17) spasticity radioimmunoassay (RIA) Ashworth score H-reflex transcutaneous electric nerve stimulation (TENS)
刊名BRAIN RESEARCH BULLETIN
2005-10-15
DOI10.1016/j.brainresbull.2005.06.026
67期:3页:189-195
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SURFACE ELECTRICAL-STIMULATION ; H-REFLEX ; INTRATHECAL BACLOFEN ; DIFFERENT FREQUENCIES ; NERVE-STIMULATION ; SHORT-TERM ; ELECTROACUPUNCTURE ; IMMUNOREACTIVITY ; TENS
英文摘要

Spasticity in rat hindlimbs was induced by compressing cervical spinal cord with a wax ball. Ashworth score and H-reflex were measured 1 week after the surgery. The results showed that: (1) muscle spasm was detected in the hindlimbs a week after the operation and maintained at least 8 weeks, (2) in the spastic animals, dynorphin A (1-17)-ir decreased significantly in thoracic and lumbar segments of the spinal cord and (3) peripheral administration Of K receptor agonist U50488H and electrical stimulation at 100 Hz effectively relieved the muscle spasm. Our data supported the note that the reduction of endogenous dynorphin A (1-17) might play an important role in the pathogenesis of spinally induced muscle spasticity and the replenishment of its shortage might relieve the spasticity. (c) 2005 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000232172200004
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57142
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
3.Minist Publ Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Dong, HW,Wang, LH,Zhang, M,et al. Decreased dynorphin A(1-17) in the spinal cord of spastic rats after the compressive injury[J]. BRAIN RESEARCH BULLETIN,2005,67(3):189-195.
APA Dong, HW,Wang, LH,Zhang, M,&Han, JS.(2005).Decreased dynorphin A(1-17) in the spinal cord of spastic rats after the compressive injury.BRAIN RESEARCH BULLETIN,67(3),189-195.
MLA Dong, HW,et al."Decreased dynorphin A(1-17) in the spinal cord of spastic rats after the compressive injury".BRAIN RESEARCH BULLETIN 67.3(2005):189-195.
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