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学科主题: 口腔医学
题名:
Different Requirements for Wnt Signaling in Tongue Myogenic Subpopulations
作者: Zhong, Z.1,2; Zhao, H.2; Mayo, J.2; Chai, Y.2
关键词: craniofacial muscles ; myogenesis ; progenitors ; Myf5 ; MyoD ; Wnt ; -catenin
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2015-03-01
DOI: 10.1177/0022034514566030
卷: 94, 期:3, 页:421-429
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: CRANIAL NEURAL CREST ; SKELETAL-MUSCLE ; TRANSCRIPTIONAL MECHANISMS ; MOUSE EMBRYOGENESIS ; PROGENITOR CELLS ; BETA-CATENIN ; STEM-CELLS ; EXPRESSION ; MYOD ; HOMEOSTASIS
英文摘要:

The tongue is a muscular organ that is essential in vertebrates for important functions, such as food intake and communication. Little is known about regulation of myogenic progenitors during tongue development when compared with the limb or trunk region. In this study, we investigated the relationship between different myogenic subpopulations and the function of canonical Wnt signaling in regulating these subpopulations. We found that Myf5- and MyoD-expressing myogenic subpopulations exist during embryonic tongue myogenesis. In the Myf5-expressing myogenic progenitors, there is a cell-autonomous requirement for canonical Wnt signaling for cell migration and differentiation. In contrast, the MyoD-expressing subpopulation does not require canonical Wnt signaling during tongue myogenesis. Taken together, our results demonstrate that canonical Wnt signaling differentially regulates the Myf5- and MyoD-expressing subpopulations during tongue myogenesis.

语种: 英语
所属项目编号: R01 DE014078
项目资助者: National Institute of Dental and Craniofacial Research, National Institutes of Health
WOS记录号: WOS:000350151400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57145
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Dept Orthodont, Sch Stomatol, Beijing 100871, Peoples R China
2.Univ So Calif, Ostrow Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA

Recommended Citation:
Zhong, Z.,Zhao, H.,Mayo, J.,et al. Different Requirements for Wnt Signaling in Tongue Myogenic Subpopulations[J]. JOURNAL OF DENTAL RESEARCH,2015,94(3):421-429.
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