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学科主题临床医学
Elevated plasma levels and monocyte-associated expression of CD137 ligand in patients with acute atherothrombotic stroke
Yu, Y.1; He, Y.1; Yang, T. -T.1; Jiang, H.1; Xiang, Y. -J.1; Fang, L. -Bo2; Hjelmstrom, P.3; Gao, X. -G.1; Liu, G. -Z.1
关键词Cd137l Ischemic Atherosclerotic Stroke Atherogenesis Peripheral Blood
刊名EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
2014-05-01
18期:10页:1525-1532
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ACUTE ISCHEMIC-STROKE ; COSTIMULATORY MOLECULES ; SOLUBLE 4-1BB ; ATHEROSCLEROSIS ; TNF ; INFLAMMATION ; SIMVASTATIN ; MATRIX-METALLOPROTEINASE-9 ; PATHOGENESIS ; ACTIVATION
英文摘要

BACKGROUND: CD137 ligand (CD137L) is expressed by various immune cells and exists in membrane-bound and soluble forms. Recently, CD137L was found to be localized to macrophages in human atherosclerotic lesions and CD137L levels were much higher in atherosclerotic lesions than in normal arteries. However, the role of CD137L with different forms in atherothrombotic stroke remains unclear.

PATIENTS AND METHODS: The soluble CD137L (sCD137L) protein and CD137L expression on monocytes were analyzed by an enzyme-linked immunosorbent assay and flow cytometry in peripheral blood of patients with acute ischemic atherosclerotic stroke, atherosclerosis controls and normal controls.

RESULTS: During the initial 24h after onset, the stroke patients had elevated plasma sCD137L levels (133.2 pg/ml) and CD137L expression on monocytes [7.9 +/- 4.1%, 7.0 +/- 4.0 mean fluorescence intensity (MFI)] as compared with normal controls (75 pg/ml, p < 0.05; 4.6 +/- 2.4%, 4.1 +/- 2.7 MFI, p < 0.05).

CONCLUSIONS: The dysregulation of CD137L expression may reflect a persistent chronic inflammatory response that may have been induced during early stages of the disease. Our results strongly suggest that the abnormal expression of CD137L on monocytes may lead to dyregulated CD137L/CD137 signaling and consequently form part of a positive-feedback, inflammation-promoting circuit in stroke, while the elevated sCD137L protein levels may function as a self-regulatory mechanism of CD137/CD137L interaction and costimulation.

语种英语
WOS记录号WOS:000341974400014
项目编号RDB2009-31 ; 81171123 ; 11220
资助机构Peking University People&prime ; s Hospital ; National Natural Science fund (NSF) ; Swedish Research Council ; Swedish Association of Neurologically Disabled
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57152
专题北京大学第二临床医学院_神经内科
作者单位1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Fuxing Hosp, Dept Neurol, Beijing, Peoples R China
3.Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
推荐引用方式
GB/T 7714
Yu, Y.,He, Y.,Yang, T. -T.,et al. Elevated plasma levels and monocyte-associated expression of CD137 ligand in patients with acute atherothrombotic stroke[J]. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES,2014,18(10):1525-1532.
APA Yu, Y..,He, Y..,Yang, T. -T..,Jiang, H..,Xiang, Y. -J..,...&Liu, G. -Z..(2014).Elevated plasma levels and monocyte-associated expression of CD137 ligand in patients with acute atherothrombotic stroke.EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES,18(10),1525-1532.
MLA Yu, Y.,et al."Elevated plasma levels and monocyte-associated expression of CD137 ligand in patients with acute atherothrombotic stroke".EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 18.10(2014):1525-1532.
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