学科主题基础医学
Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery
Li, Ang1; Dong, Lei1; Duan, Mei-Li1; Sun, Kai2,3; Liu, Yu-Ying2,3; Wang, Ming-Xia2,3; Deng, Jing-Na2,3; Fan, Jing-Yu2,3; Wang, Bao-En1; Han, Jing-Yan2,3,4,5
关键词Toll-like Receptor 4 Nuclear Factor Kappa b P65 Activator Protein-1 Adhesion Molecules Rheum Palmatum
刊名MICROCIRCULATION
2013-10-01
DOI10.1111/micc.12061
20期:7页:617-628
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]KAPPA-B ACTIVATION ; ENDOTHELIAL-CELLS ; EXPRESSION ; SECRETION ; MONOCYTES ; ADHESION ; SEPSIS
英文摘要

ObjectiveSepsis is a systemic inflammatory response syndrome. Emodin is a major ingredient of Rheum Palmatum, a Chinese herb that is widely used in China for treatment of endotoxemia-related diseases. This study intended to examine the effect of Emodin on LPS-induced rat mesenteric microcirculatory disturbance and the underlying mechanisms.

MethodsThe male Wistar rats received LPS (5 mg/kg/hr) for 90 min, with or without administration of Emodin (10 mg/kg/hr) by enema 30 min before (pre-treatment) or after (post-treatment) LPS infusion, and the dynamics of mesenteric microcirculation were determined by inverted intravital microscopy. Expression of adhesion molecules and TLR4, NF-B p65, ICAM-1, MPO, and AP-1 in mesentery tissue was evaluated by flow cytometry and Western-blot, respectively.

ResultsPre or post-treatment with Emodin significantly ameliorated LPS-induced leukocyte emigration, reactive oxygen species production and albumin leakage, and the expression of TLR4, NF-B p65, ICAM-1, MPO and AP-1 in mesentery.

ConclusionsThese results demonstrate the beneficial role of Emodin in attenuating the LPS-induced microcirculatory disturbance, and support the use of Emodin for patients with endotoxemia.

语种英语
WOS记录号WOS:000325612800005
项目编号2008ZX09401
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57153
专题北京大学基础医学院_北大医学部天士力微循环研究中心
北京大学基础医学院
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
3.State Adm Tradit Chinese Med China, Key Lab Microcirculat, Beijing, Peoples R China
4.Peking Univ, Dept Integrat Chinese & Western Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
5.Minist Educ China, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
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GB/T 7714
Li, Ang,Dong, Lei,Duan, Mei-Li,et al. Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery[J]. MICROCIRCULATION,2013,20(7):617-628.
APA Li, Ang.,Dong, Lei.,Duan, Mei-Li.,Sun, Kai.,Liu, Yu-Ying.,...&Han, Jing-Yan.(2013).Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery.MICROCIRCULATION,20(7),617-628.
MLA Li, Ang,et al."Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery".MICROCIRCULATION 20.7(2013):617-628.
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