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学科主题: 基础医学
题名:
Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery
作者: Li, Ang1; Dong, Lei1; Duan, Mei-Li1; Sun, Kai2,3; Liu, Yu-Ying2,3; Wang, Ming-Xia2,3; Deng, Jing-Na2,3; Fan, Jing-Yu2,3; Wang, Bao-En1; Han, Jing-Yan2,3,4,5
关键词: toll-like receptor 4 ; nuclear factor kappa B p65 ; activator protein-1 ; adhesion molecules ; Rheum palmatum
刊名: MICROCIRCULATION
发表日期: 2013-10-01
DOI: 10.1111/micc.12061
卷: 20, 期:7, 页:617-628
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: KAPPA-B ACTIVATION ; ENDOTHELIAL-CELLS ; EXPRESSION ; SECRETION ; MONOCYTES ; ADHESION ; SEPSIS
英文摘要:

ObjectiveSepsis is a systemic inflammatory response syndrome. Emodin is a major ingredient of Rheum Palmatum, a Chinese herb that is widely used in China for treatment of endotoxemia-related diseases. This study intended to examine the effect of Emodin on LPS-induced rat mesenteric microcirculatory disturbance and the underlying mechanisms.

MethodsThe male Wistar rats received LPS (5 mg/kg/hr) for 90 min, with or without administration of Emodin (10 mg/kg/hr) by enema 30 min before (pre-treatment) or after (post-treatment) LPS infusion, and the dynamics of mesenteric microcirculation were determined by inverted intravital microscopy. Expression of adhesion molecules and TLR4, NF-B p65, ICAM-1, MPO, and AP-1 in mesentery tissue was evaluated by flow cytometry and Western-blot, respectively.

ResultsPre or post-treatment with Emodin significantly ameliorated LPS-induced leukocyte emigration, reactive oxygen species production and albumin leakage, and the expression of TLR4, NF-B p65, ICAM-1, MPO and AP-1 in mesentery.

ConclusionsThese results demonstrate the beneficial role of Emodin in attenuating the LPS-induced microcirculatory disturbance, and support the use of Emodin for patients with endotoxemia.

语种: 英语
所属项目编号: 2008ZX09401
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000325612800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57153
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Friendship Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
3.State Adm Tradit Chinese Med China, Key Lab Microcirculat, Beijing, Peoples R China
4.Peking Univ, Dept Integrat Chinese & Western Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
5.Minist Educ China, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China

Recommended Citation:
Li, Ang,Dong, Lei,Duan, Mei-Li,et al. Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery[J]. MICROCIRCULATION,2013,20(7):617-628.
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