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学科主题: 临床医学
题名:
Results after change of treatment policy for rectal cancer - report from a single hospital in China
作者: Wu, A. W.; Gu, J.; Wang, J.; Ye, S. W.; An, Q.; Yao, Y. F.; Zhan, T. C.
关键词: rectal cancer ; treatment ; total mesorectal excision
刊名: EJSO
发表日期: 2007-08-01
DOI: 10.1016/j.ejso.2006.12.011
卷: 33, 期:6, 页:718-723
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: TOTAL MESORECTAL EXCISION ; ADVANCED COLORECTAL-CANCER ; LOCAL RECURRENCE ; CIRCUMFERENTIAL MARGIN ; PELVIC RECURRENCE ; ADJUVANT THERAPY ; SURGERY ; CARCINOMA ; SURVIVAL ; PRESERVATION
英文摘要:

Background: Great changes have occurred in the management of rectal cancer. This study presents the outcome of total mesorectal excision (TME) for rectal cancer in a single Chinese institution and evaluates TME′s role in the comprehensive management of rectal cancer.

Methods: We reviewed the data of rectal cancer patients surgically treated by three colorectal surgeons from January 2000 to August 2004. Patients who received surgical resection for rectal cancer from January 1996 to December 1999, before the introduction of TME, were chosen as controls. Data regarding characteristics of patients and tumors, surgical procedures, postoperative complications, and results of follow-up were collected for analysis.

Results: Three hundred and seventy-seven patients with rectal cancer were enrolled in our study, with 175 patients in the THE group and 202 as controls. Mortality and morbidity rates were 1% and 14% in THE patients and 1 % and 31 % in controls, respectively. The THE group had a shorter operation time and hospital stay, and less bleeding, wound and urinary complications. The local recurrence (LR) rate was 6% and 12% in the THE and the control groups, respectively (P < 0.05). With a median follow-up of 35 months, the actuarial 5-year survival rate was 66%. Consistent with the univariate analysis result, multivariate analysis demonstrated that TNM stage, tumor grade, age, and surgeons were independent prognostic factors. THE was not an independent prognostic factor for patients′ survival.

Conclusions: THE is a safe and efficient option in reducing LR. However, it is not an independent predictor for patients′ survival. In addition to the standardized usage of TME, further knowledge on the molecular mechanism of cancer is needed. (c) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000248935300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57155
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Beijing Canc Hosp, Beijing Inst Canc Res, Sch Oncol,Dept Colorectal Surg, Beijing 100036, Peoples R China

Recommended Citation:
Wu, A. W.,Gu, J.,Wang, J.,et al. Results after change of treatment policy for rectal cancer - report from a single hospital in China[J]. EJSO,2007,33(6):718-723.
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