IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Results after change of treatment policy for rectal cancer - report from a single hospital in China
Wu, A. W.; Gu, J.; Wang, J.; Ye, S. W.; An, Q.; Yao, Y. F.; Zhan, T. C.
关键词Rectal Cancer Treatment Total Mesorectal Excision
刊名EJSO
2007-08-01
DOI10.1016/j.ejso.2006.12.011
33期:6页:718-723
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]TOTAL MESORECTAL EXCISION ; ADVANCED COLORECTAL-CANCER ; LOCAL RECURRENCE ; CIRCUMFERENTIAL MARGIN ; PELVIC RECURRENCE ; ADJUVANT THERAPY ; SURGERY ; CARCINOMA ; SURVIVAL ; PRESERVATION
英文摘要

Background: Great changes have occurred in the management of rectal cancer. This study presents the outcome of total mesorectal excision (TME) for rectal cancer in a single Chinese institution and evaluates TME′s role in the comprehensive management of rectal cancer.

Methods: We reviewed the data of rectal cancer patients surgically treated by three colorectal surgeons from January 2000 to August 2004. Patients who received surgical resection for rectal cancer from January 1996 to December 1999, before the introduction of TME, were chosen as controls. Data regarding characteristics of patients and tumors, surgical procedures, postoperative complications, and results of follow-up were collected for analysis.

Results: Three hundred and seventy-seven patients with rectal cancer were enrolled in our study, with 175 patients in the THE group and 202 as controls. Mortality and morbidity rates were 1% and 14% in THE patients and 1 % and 31 % in controls, respectively. The THE group had a shorter operation time and hospital stay, and less bleeding, wound and urinary complications. The local recurrence (LR) rate was 6% and 12% in the THE and the control groups, respectively (P < 0.05). With a median follow-up of 35 months, the actuarial 5-year survival rate was 66%. Consistent with the univariate analysis result, multivariate analysis demonstrated that TNM stage, tumor grade, age, and surgeons were independent prognostic factors. THE was not an independent prognostic factor for patients′ survival.

Conclusions: THE is a safe and efficient option in reducing LR. However, it is not an independent predictor for patients′ survival. In addition to the standardized usage of TME, further knowledge on the molecular mechanism of cancer is needed. (c) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000248935300010
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57155
专题北京大学临床肿瘤学院
作者单位Peking Univ, Beijing Canc Hosp, Beijing Inst Canc Res, Sch Oncol,Dept Colorectal Surg, Beijing 100036, Peoples R China
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GB/T 7714
Wu, A. W.,Gu, J.,Wang, J.,et al. Results after change of treatment policy for rectal cancer - report from a single hospital in China[J]. EJSO,2007,33(6):718-723.
APA Wu, A. W..,Gu, J..,Wang, J..,Ye, S. W..,An, Q..,...&Zhan, T. C..(2007).Results after change of treatment policy for rectal cancer - report from a single hospital in China.EJSO,33(6),718-723.
MLA Wu, A. W.,et al."Results after change of treatment policy for rectal cancer - report from a single hospital in China".EJSO 33.6(2007):718-723.
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