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学科主题基础医学
Combined lysosomal protein transmembrane 4 beta-35 and argininosuccinate synthetase expression predicts clinical outcome in hepatocellular carcinoma patients
Yang, Hua1; Lin, Ming1; Xiong, Fuxia1; Yang, Yu2; Nie, Xiu3; McNutt, Michael A.2; Zhou, Rouli1
关键词Lysosomal Protein Transmembrane 4 Beta Argininosuccinate Synthetase Hepatocellular Carcinoma Immunohistochemistry Prognosis
刊名SURGERY TODAY
2011-06-01
DOI10.1007/s00595-010-4338-5
41期:6页:810-817
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]ARGININE DEPRIVATION ; GROWTH-INHIBITION ; MALIGNANT-CELLS ; NITRIC-OXIDE ; UREA CYCLE ; IN-VITRO ; DEIMINASE ; CANCER ; PROLIFERATION ; METABOLISM
英文摘要

The newly-identified lysosomal protein transmembrane 4 beta-35 (LAPTM4B-35) plays important roles in tumor progression and metastasis, while argininosuccinate synthetase (ASS) provides arginine as an indispensable nutrient for hepatocellular carcinoma (HCC). The present study investigated the clinical significance of the coexpression of LAPTM4B-35 and ASS in HCC patients on determining the prognosis.

Immunohistochemistry was used to evaluate the expression of LAPTM4B-35 and ASS in HCC tissues and paired noncancerous liver samples from 71 patients. The correlation of combined LAPTM4B-35 and ASS expression with selected clinicopathologic parameters was assessed with the chi-squared test. Patient survival and differences in survival were determined by the Kaplan-Meier method and the log-rank test. A Cox regression analysis was adopted for a multivariate analysis of the prognostic factors.

Combined LAPTM4B-35 and ASS expression was significantly associated with TNM stage and portal vein invasion. In addition, patients with HCCs expressing both LAPTM4B-35 and ASS exhibited both markedly poorer overall survival (OS) and disease-free survival (DFS) (both P < 0.001). According to the multivariate analyses, combined LAPTM4B-35 and ASS expression was found to be an independent prognostic factor for OS and DFS (P = 0.039 and P = 0.035, respectively).

The overexpression of LAPTM4B-35 in combination with positive ASS expression is a negative prognostic marker for HCC.

语种英语
WOS记录号WOS:000291056300012
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57171
专题北京大学基础医学院_细胞生物学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pathol, Wuhan 430022, Peoples R China
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GB/T 7714
Yang, Hua,Lin, Ming,Xiong, Fuxia,et al. Combined lysosomal protein transmembrane 4 beta-35 and argininosuccinate synthetase expression predicts clinical outcome in hepatocellular carcinoma patients[J]. SURGERY TODAY,2011,41(6):810-817.
APA Yang, Hua.,Lin, Ming.,Xiong, Fuxia.,Yang, Yu.,Nie, Xiu.,...&Zhou, Rouli.(2011).Combined lysosomal protein transmembrane 4 beta-35 and argininosuccinate synthetase expression predicts clinical outcome in hepatocellular carcinoma patients.SURGERY TODAY,41(6),810-817.
MLA Yang, Hua,et al."Combined lysosomal protein transmembrane 4 beta-35 and argininosuccinate synthetase expression predicts clinical outcome in hepatocellular carcinoma patients".SURGERY TODAY 41.6(2011):810-817.
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