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A new sesquiterpene lactone from Tsoongiodendron odorum Chun
Song, XK; Tu, PF; Wu, LJ; Cai, Y; Zhu, H; Lu, Y; Liu, XY; Zheng, QT
关键词Tsoongiodendron Odorum Chun Sesquiterpene Lactones Cytotoxic Activity
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2001
3期:4页:285-291
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]ASSAY
英文摘要

A new sesquiterpene lactone (1) was obtained from the cytotoxic fraction of 95% ethanol extract of root barks of Tsoongiodendron odorum Chun together with two known sesquiterpene lactones, costunolide (2) and parthenolide (3). The structure of 1 was elucidated as 5 alpha, 6 alpha, 7 beta, 10 beta - 11 alpha, 13-dihydro-4(15)-eudesmene-12, 6-olide on the basis of chemical and spectral evidence including X-ray diffraction analysis. Costunolide showed cytotoxic activity against human leukemia (HL-60) cell line. Parthenolide showed promising cytotoxic activities in vitro against HCT-8, Bel-7402, SKOV3, KB, HELA and EJ cell lines. Also, the cytotoxic ethyl acetate fraction of ethanol extract of the root barks from which three chemical components were isolated showed promising cytotoxic activities in vitro against KB, BGC-823, Bel-7402, HCT-8, HL-60 cell lines.

语种英语
WOS记录号WOS:000173008700006
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57179
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang 110015, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
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GB/T 7714
Song, XK,Tu, PF,Wu, LJ,et al. A new sesquiterpene lactone from Tsoongiodendron odorum Chun[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2001,3(4):285-291.
APA Song, XK.,Tu, PF.,Wu, LJ.,Cai, Y.,Zhu, H.,...&Zheng, QT.(2001).A new sesquiterpene lactone from Tsoongiodendron odorum Chun.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,3(4),285-291.
MLA Song, XK,et al."A new sesquiterpene lactone from Tsoongiodendron odorum Chun".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 3.4(2001):285-291.
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