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学科主题: 药学
题名:
A new sesquiterpene lactone from Tsoongiodendron odorum Chun
作者: Song, XK; Tu, PF; Wu, LJ; Cai, Y; Zhu, H; Lu, Y; Liu, XY; Zheng, QT
关键词: Tsoongiodendron odorum Chun ; sesquiterpene lactones ; cytotoxic activity
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2001
卷: 3, 期:4, 页:285-291
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ASSAY
英文摘要:

A new sesquiterpene lactone (1) was obtained from the cytotoxic fraction of 95% ethanol extract of root barks of Tsoongiodendron odorum Chun together with two known sesquiterpene lactones, costunolide (2) and parthenolide (3). The structure of 1 was elucidated as 5 alpha, 6 alpha, 7 beta, 10 beta - 11 alpha, 13-dihydro-4(15)-eudesmene-12, 6-olide on the basis of chemical and spectral evidence including X-ray diffraction analysis. Costunolide showed cytotoxic activity against human leukemia (HL-60) cell line. Parthenolide showed promising cytotoxic activities in vitro against HCT-8, Bel-7402, SKOV3, KB, HELA and EJ cell lines. Also, the cytotoxic ethyl acetate fraction of ethanol extract of the root barks from which three chemical components were isolated showed promising cytotoxic activities in vitro against KB, BGC-823, Bel-7402, HCT-8, HL-60 cell lines.

语种: 英语
WOS记录号: WOS:000173008700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57179
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang 110015, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

Recommended Citation:
Song, XK,Tu, PF,Wu, LJ,et al. A new sesquiterpene lactone from Tsoongiodendron odorum Chun[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2001,3(4):285-291.
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