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学科主题: 临床医学
题名:
Melamine-Contaminated Powdered Formula and Urolithiasis in Young Children.
作者: Guan, Na1; Fan, Qingfeng1; Ding, Jie1; Zhao, Yiming2; Lu, Jingqiao2; Ai, Yi1; Xu, Guobin1; Zhu, Sainan1; Yao, Chen1; Jiang, Lina1; Miao, Jing1; Zhang, Han1; Zhao, Dan1; Liu, Xiaoyu1; Yao, Yong1
刊名: NEW ENGLAND JOURNAL OF MEDICINE
发表日期: 2009-03-12
DOI: 10.1056/NEJMoa0809550
卷: 360, 期:11, 页:1067-1074
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要:

Background: A recent epidemic of melamine contamination of baby formula in China has been associated with the development of urinary tract stones, though the clinical manifestations and predisposing factors are incompletely delineated.

Methods: We administered a questionnaire to the parents of children 36 months of age or younger who were being screened for a history of exposure to melamine and symptoms of, and possible predisposing factors for, urinary tract stones. In addition, we performed urinalysis, renal-function and liver-function tests, urinary tests for biochemical markers and the calcium:creatinine ratio, and ultrasonography. Powdered-milk infant formulas were classified as having a high melamine content (>500 ppm), a moderate melamine content (<150 ppm), or no melamine (0 ppm); no formulas contained between 150 and 500 ppm of melamine.

Results: Contaminated formula was ingested by 421 of 589 children. Fifty had urinary stones, including 8 who had not received melamine-contaminated formula; 112 were suspected to have stones; and 427 had no stones. Among children with stones, 5.9% had hematuria and 2.9% had leukocyturia, percentages that did not differ significantly from those among children who were suspected to have stones or those who did not have stones. Serum creatinine, urea nitrogen, and alanine aminotransferase levels were normal in the 22 children with stones who were tested. Four of the 41 children (9.8%) who had stones and in whom urinary markers of glomerular function were measured had evidence of abnormalities; none had tubular dysfunction. Children exposed to high-melamine formula were 7.0 times as likely to have stones as those exposed to no-melamine formula. Preterm infants were 4.5 times as likely to have stones as term infants.

Conclusions: Prematurity and exposure to melamine-contaminated formula were associated with urinary stones. Affected children lacked typical signs and symptoms of urolithiasis.

N Engl J Med 2009;360:1067-74.

语种: 英语
项目资助者: National Key Technology Research and Development Program of China
WOS记录号: WOS:000264051000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57182
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing 100034, Peoples R China

Recommended Citation:
Guan, Na,Fan, Qingfeng,Ding, Jie,et al. Melamine-Contaminated Powdered Formula and Urolithiasis in Young Children.[J]. NEW ENGLAND JOURNAL OF MEDICINE,2009,360(11):1067-1074.
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