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学科主题: 药学
题名:
Anti-inflammatory lignanamides from the roots of Solanum melongena L.
作者: Sun, Jing1,2; Gu, Yu-Fan1,2; Su, Xiao-Qin1,2; Li, Man-Man1,2; Huo, Hui-Xia1,2; Zhang, Jing1,2; Zeng, Ke-Wu3; Zhang, Qian1; Zhao, Yun-Fang1; Li, Jun1; Tu, Peng-Fei1
关键词: Solanaceae ; Solanum melongena L. ; Lignanamide ; Anti-inflammation
刊名: FITOTERAPIA
发表日期: 2014-10-01
DOI: 10.1016/j.fitote.2014.07.012
卷: 98, 页:110-116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE ; PHENOLIC-COMPOUNDS ; RABDOSIA-JAPONICA ; CANNABIS-SATIVA ; CAFFEIC ACID ; FRUITS ; NEOLIGNANS ; CONSTITUENTS ; INFLAMMATION ; ALKALOIDS
英文摘要:

Four new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10), were isolated from the roots of Solanum melongena L. Their structures were elucidated on the basis of 1D and 2D NMR experiments and by comparison of their spectroscopic and physical data with the literature values. Compounds 2-8 exhibited inhibitions of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values ranging from 16.2 to 58.5 mu M. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: NCET-13-0693 ; CP2015
项目资助者: Program for New Century Excellent Talents in University ; Project of Standards Improvement of TCM ; Ministry of Industry and Information Technology of P.R. China
WOS记录号: WOS:000343617600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57183
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Jing,Gu, Yu-Fan,Su, Xiao-Qin,et al. Anti-inflammatory lignanamides from the roots of Solanum melongena L.[J]. FITOTERAPIA,2014,98:110-116.
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