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学科主题: 基础医学
题名:
Attenuating effect of Myakuryu on mesenteric microcirculatory disorders induced by ischemia and reperfusion
作者: Han, JY; Horie, Y; Li, D; Akiba, Y; Nagata, H; Miura, S; Oda, M; Ishii, H; Hibi, T
关键词: Chinese medicine ; oxygen radicals ; leukocyte adherence ; mast cell degranulation ; ischemia-reperfusion
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2006
卷: 34, 期:1-2, 页:145-150
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: INDUCED MICROVASCULAR DYSFUNCTION ; GINKGO-BILOBA EXTRACT ; NF-KAPPA-B ; MAST-CELLS ; DIHYDRORHODAMINE 123 ; RAT MESENTERY ; ISCHEMIA/REPERFUSION ; ACTIVATION ; INJURY ; EXPRESSION
英文摘要:

Myakuryu (MR) is a newly developed herbal medicine composing Crataegue oinnatifida bge (COB), Panax notoginseng (PN) and Ginkyo biloba (GB). To examine the effectiveness of MR, we investigated its effects on rat mesenteric microcirculatory injury induced by ischemia/reperfusion (I/R). The mesenteric microcirculation of ileocecal portion of a male Wistar rat was observed through an inverted-type intravital microscope assisted with a charge-coupled devise (CCD) camera. Mesenteric I/R was conducted by a ligation of the mesenteric artery and vein (10 min) and subsequent release of the occlusion. We measured venular diameter, the number of adherent leukocytes, dihydrorhodamine 123 (DHR) fluorescence as an indicator of oxidative stress and mast cell degranulation, with or without MR extract (0.4 g/kg b.w.) via an orogastric tube 1hr before I/R. The diameters of the observed mesenteric venules were not changed after the mesenteric I/R. MR had no effect on venular diameter. The leukocytes adhering to the post-capillary venular walls started just after reperfusion, and increased thereafter. The increased number of adherent leukocytes was significantly reduced by treatment with MR. DHR fluorescence ratio was significantly increased along the venular wall. MR attenuated the increased oxidation. The mesenteric I/R induced mast cell degranulation. The increase in mast cell degranulation was inhibited by MR. In conclusion, oral administration of MR attenuates I/R-induced microvascular damages in rat mesentery. MR has a therapeutic potential for prevention of I/R-related microvascular injury.

语种: 英语
WOS记录号: WOS:000236802600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57188
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
2.Sanno Hosp, Int Univ Hlth & Welf, Tokyo, Japan
3.Sanno Hosp, Dept Internal Med, Tokyo, Japan
4.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
5.Natl Def Med Coll, Dept Internal Med 2, Saitama, Japan

Recommended Citation:
Han, JY,Horie, Y,Li, D,et al. Attenuating effect of Myakuryu on mesenteric microcirculatory disorders induced by ischemia and reperfusion[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2006,34(1-2):145-150.
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