IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignancies
Chang, Ying-Jun; Zhao, Xiang-Yu; Huo, Ming-Rui; Xu, Lan-Ping; Liu, Dai-Hong; Liu, Kai-Yan; Huang, Xiao-Jun
刊名AMERICAN JOURNAL OF HEMATOLOGY
2011-02-01
DOI10.1002/ajh.21921
86期:2页:227-230
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]STEM-CELL TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; PREDICTS SUPERIOR SURVIVAL ; MATCHED SIBLING DONORS ; VERSUS-HOST-DISEASE ; MULTIPLE-MYELOMA ; ALLOGENEIC BLOOD ; CHRONIC GRAFT ; RECOVERY ; RECONSTITUTION
英文摘要

Currently, limited information is available regarding the effects of early lymphocyte recovery on transplant outcomes in pediatric patients with hematological malignancies after unmanipulated haploidentical transplantation. In this study, we evaluated the association of Day 30 absolute lymphocyte count (ALC-30) with transplant outcomes in 60 consecutive pediatric paients with hematological malignancies receiving T-cell-repleted transplantation from an haploidentical related donors. After median follow-up of 36 months (range, 1.4-75 months), higher relapse rate was observed in patients with an ALC-30 < 300 cells/mu L compared to patients with an ALC-30 >= 300 cells/mu L (35.5% vs. 13.8%, P = 0.049). More patients died of infections in those with an ALC-30 < 300 cells/mu L compared with patients with an ALC-30 >= 300 cells/mu L (25.8% vs. 3.4%, P = 0.015). The ALC-30 above the cutoff value 300 cells/mu L was associated with improved overall-survival (HR 0.301, 95% CI 0.117-0.771; P = 0.012), leukemia free survival (HR 0.195, 95% CI 0.078-0.498; P=0.002), less relapse (HR 0.224 95% CI 0.070-0.717; P = 0.012), and less transplant-related mortality (HR=0.166; 95% CI 0.037-0.750; P = 0.020). Our results suggest that a higher ALC-30 >= 300 cells/mu L) could be a useful and simple tool to predict pediatric patients with a superior outcome after unmanipulated haploidentical transplantation.

语种英语
WOS记录号WOS:000287151700022
项目编号30725038 ; 30971292 ; 2006AA02Z4A0 ; IRT0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57196
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,et al. Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignancies[J]. AMERICAN JOURNAL OF HEMATOLOGY,2011,86(2):227-230.
APA Chang, Ying-Jun.,Zhao, Xiang-Yu.,Huo, Ming-Rui.,Xu, Lan-Ping.,Liu, Dai-Hong.,...&Huang, Xiao-Jun.(2011).Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignancies.AMERICAN JOURNAL OF HEMATOLOGY,86(2),227-230.
MLA Chang, Ying-Jun,et al."Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignancies".AMERICAN JOURNAL OF HEMATOLOGY 86.2(2011):227-230.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chang, Ying-Jun]的文章
[Zhao, Xiang-Yu]的文章
[Huo, Ming-Rui]的文章
百度学术
百度学术中相似的文章
[Chang, Ying-Jun]的文章
[Zhao, Xiang-Yu]的文章
[Huo, Ming-Rui]的文章
必应学术
必应学术中相似的文章
[Chang, Ying-Jun]的文章
[Zhao, Xiang-Yu]的文章
[Huo, Ming-Rui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。