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学科主题: 临床医学
题名:
Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignancies
作者: Chang, Ying-Jun; Zhao, Xiang-Yu; Huo, Ming-Rui; Xu, Lan-Ping; Liu, Dai-Hong; Liu, Kai-Yan; Huang, Xiao-Jun
刊名: AMERICAN JOURNAL OF HEMATOLOGY
发表日期: 2011-02-01
DOI: 10.1002/ajh.21921
卷: 86, 期:2, 页:227-230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: STEM-CELL TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; PREDICTS SUPERIOR SURVIVAL ; MATCHED SIBLING DONORS ; VERSUS-HOST-DISEASE ; MULTIPLE-MYELOMA ; ALLOGENEIC BLOOD ; CHRONIC GRAFT ; RECOVERY ; RECONSTITUTION
英文摘要:

Currently, limited information is available regarding the effects of early lymphocyte recovery on transplant outcomes in pediatric patients with hematological malignancies after unmanipulated haploidentical transplantation. In this study, we evaluated the association of Day 30 absolute lymphocyte count (ALC-30) with transplant outcomes in 60 consecutive pediatric paients with hematological malignancies receiving T-cell-repleted transplantation from an haploidentical related donors. After median follow-up of 36 months (range, 1.4-75 months), higher relapse rate was observed in patients with an ALC-30 < 300 cells/mu L compared to patients with an ALC-30 >= 300 cells/mu L (35.5% vs. 13.8%, P = 0.049). More patients died of infections in those with an ALC-30 < 300 cells/mu L compared with patients with an ALC-30 >= 300 cells/mu L (25.8% vs. 3.4%, P = 0.015). The ALC-30 above the cutoff value 300 cells/mu L was associated with improved overall-survival (HR 0.301, 95% CI 0.117-0.771; P = 0.012), leukemia free survival (HR 0.195, 95% CI 0.078-0.498; P=0.002), less relapse (HR 0.224 95% CI 0.070-0.717; P = 0.012), and less transplant-related mortality (HR=0.166; 95% CI 0.037-0.750; P = 0.020). Our results suggest that a higher ALC-30 >= 300 cells/mu L) could be a useful and simple tool to predict pediatric patients with a superior outcome after unmanipulated haploidentical transplantation.

语种: 英语
所属项目编号: 30725038 ; 30971292 ; 2006AA02Z4A0 ; IRT0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University
WOS记录号: WOS:000287151700022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57196
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,et al. Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignancies[J]. AMERICAN JOURNAL OF HEMATOLOGY,2011,86(2):227-230.
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