IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所
学科主题临床医学
Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: A meta-analysis
Yang, Ming; Rao, Hui-Ying; Feng, Bo; Zhang, Wei; Wei, Lai
关键词Hepatitis c Virus Human Interleukin 28b Single Nucleotide Polymorphisms Spontaneous Clearance
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2013-07-01
DOI10.1111/jgh.12233
28期:7页:1114-1121
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者National Science and Technology Major Project for Infectious Diseases Control ; National Science and Technology Major Project for Infectious Diseases Control
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]GENOME-WIDE ASSOCIATION ; HOST GENETIC-DETERMINANTS ; INDUCED VIRAL CLEARANCE ; IL28B POLYMORPHISMS ; PREDICTIVE-VALUE ; NATURAL-HISTORY ; HCV INFECTION ; COHORT ; EPIDEMIOLOGY ; VARIANTS
英文摘要

Background and Aim Recent studies suggested that interleukin 28B (IL28B) polymorphisms may affect spontaneous clearance (SC) of hepatitis C virus (HCV) infection. Our purpose was to update the meta-analysis to reevaluate the impact of IL28B rs12979860 and rs8099917 polymorphisms on SC in patients infected with HCV. Methods We searched PubMed, Web of Science, and Embase up to February 2013. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by fixed- or random-effects models. Heterogeneity, sensitivity analysis, and publication bias were also assessed. Results Seventeen eligible papers were involved in this study. The SC rate was higher in patients with the rs12979860 CC (vsCT/TT OR=2.98, 95% CI 2.53-3.50) and rs8099917 TT (vsGT/GG OR=2.80, 95% CI 2.23-3.51) in the IL28B polymorphisms. Ethnicity stratification revealed that rs12979860 CC was associated with SC for Caucasians (vsCT/TT OR=3.05, 95% CI 2.67-3.49), Asians (vsCT/TT OR=1.88, 95% CI 1.33-2.66), and Africans (vsCT/TT OR=3.15, 95% CI 2.39-4.15); rs8099917 TT was associated with SC for Caucasians (vsGT/GG OR=2.48, 95% CI 1.96-3.15). Conclusions IL28B rs12979860 and rs8099917 single nucleotide polymorphisms are significantly associated with SC of HCV infection. The predictive value of rs12979860 CC was stronger in Caucasians and Africans than in Asians.

语种英语
所属项目编号2008ZX10002-012 ; 2008ZX10002-013 ; 2012ZX10002003
资助者National Science and Technology Major Project for Infectious Diseases Control ; National Science and Technology Major Project for Infectious Diseases Control
WOS记录号WOS:000320722200010
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57207
Collection北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Yang, Ming,Rao, Hui-Ying,Feng, Bo,et al. Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: A meta-analysis[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2013,28(7):1114-1121.
APA Yang, Ming,Rao, Hui-Ying,Feng, Bo,Zhang, Wei,&Wei, Lai.(2013).Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: A meta-analysis.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,28(7),1114-1121.
MLA Yang, Ming,et al."Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: A meta-analysis".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 28.7(2013):1114-1121.
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