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Efficient preparation of derivatives of resibufogenin using microbial catalytic technique
Zhan, JX; Guo, HZ; Ning, LL; Zhang, YX; Guo, D
关键词Resibufogenin Microbial Transformation Mucor Subtilissimus Hydroxylation Isomerization Glucosylation
刊名PLANTA MEDICA
2006-03-01
DOI10.1055/s-2005-916231
72期:4页:346-350
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]TOAD VENOM ; BUFADIENOLIDES
英文摘要

Microbial catalysis is a useful biotechnology in studies on natural products, by which a diversity of novel or active compounds can be obtained. Structural modifications of resibufogenin (1) by hydroxylases, isomerase and glucosyltransferase in Mucor subtilissimus AS 3.2454 were investigated. Eleven products were obtained, and, on the basis of their spectral data, their structures were identified as 12 beta-hydroxyresibufogenin (2), 11 beta-hydroxyresibufogenin (3), 16 alpha-hydroxyresibufogenin (4), 12 beta-hydroxy-3epi-resibufogenin (5), 12 alpha-hydroxyresibufogenin (6), 1 beta,11 beta-dihydroxyresibufogenin (7), 12 beta,16 alpha-dihydroxyresibufogenin (8), 12 alpha,16 alpha-dihydroxyresibufogenin (9), 7 alpha-hydroxyresibufogenin (10), 1 beta 12 beta-dihydroxyresibufogenin (11) and resibufogenin 120-beta-D-glucoside (12), respectively, of which 3, 5, 7, 11 and 12 are new compounds. This microbial catalytic process was efficient for the production of derivatives of resibufogenin giving I I products and an overall yield of 93.60%.

语种英语
WOS记录号WOS:000236670700010
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57209
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China
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Zhan, JX,Guo, HZ,Ning, LL,et al. Efficient preparation of derivatives of resibufogenin using microbial catalytic technique[J]. PLANTA MEDICA,2006,72(4):346-350.
APA Zhan, JX,Guo, HZ,Ning, LL,Zhang, YX,&Guo, D.(2006).Efficient preparation of derivatives of resibufogenin using microbial catalytic technique.PLANTA MEDICA,72(4),346-350.
MLA Zhan, JX,et al."Efficient preparation of derivatives of resibufogenin using microbial catalytic technique".PLANTA MEDICA 72.4(2006):346-350.
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