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学科主题: 药学
题名:
Efficient preparation of derivatives of resibufogenin using microbial catalytic technique
作者: Zhan, JX; Guo, HZ; Ning, LL; Zhang, YX; Guo, D
关键词: resibufogenin ; microbial transformation ; Mucor subtilissimus ; hydroxylation ; isomerization ; glucosylation
刊名: PLANTA MEDICA
发表日期: 2006-03-01
DOI: 10.1055/s-2005-916231
卷: 72, 期:4, 页:346-350
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: TOAD VENOM ; BUFADIENOLIDES
英文摘要:

Microbial catalysis is a useful biotechnology in studies on natural products, by which a diversity of novel or active compounds can be obtained. Structural modifications of resibufogenin (1) by hydroxylases, isomerase and glucosyltransferase in Mucor subtilissimus AS 3.2454 were investigated. Eleven products were obtained, and, on the basis of their spectral data, their structures were identified as 12 beta-hydroxyresibufogenin (2), 11 beta-hydroxyresibufogenin (3), 16 alpha-hydroxyresibufogenin (4), 12 beta-hydroxy-3epi-resibufogenin (5), 12 alpha-hydroxyresibufogenin (6), 1 beta,11 beta-dihydroxyresibufogenin (7), 12 beta,16 alpha-dihydroxyresibufogenin (8), 12 alpha,16 alpha-dihydroxyresibufogenin (9), 7 alpha-hydroxyresibufogenin (10), 1 beta 12 beta-dihydroxyresibufogenin (11) and resibufogenin 120-beta-D-glucoside (12), respectively, of which 3, 5, 7, 11 and 12 are new compounds. This microbial catalytic process was efficient for the production of derivatives of resibufogenin giving I I products and an overall yield of 93.60%.

语种: 英语
WOS记录号: WOS:000236670700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57209
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China

Recommended Citation:
Zhan, JX,Guo, HZ,Ning, LL,et al. Efficient preparation of derivatives of resibufogenin using microbial catalytic technique[J]. PLANTA MEDICA,2006,72(4):346-350.
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