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学科主题: 临床医学
题名:
Accuracy of diagnosing gastroesophageal reflux disease by GerdQ, esophageal impedance monitoring and histology
作者: Zhou, Li Ya; Wang, Ye; Lu, Jing Jing; Lin, Lin; Cui, Rong Li; Zhang, He Jun; Xue, Yan; Ding, Shi Gang; Lin, San Ren
关键词: impedance ; intercellular space ; gastroesophageal reflux disease ; gastroesophageal reflux disease questionnaire
刊名: JOURNAL OF DIGESTIVE DISEASES
发表日期: 2014-05-01
DOI: 10.1111/1751-2980.12135
卷: 15, 期:5, 页:230-238
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: NORMAL VALUES ; QUESTIONNAIRE ; MANAGEMENT ; EPIDEMIOLOGY ; VALIDATION ; ENDOSCOPY ; SYMPTOMS ; THERAPY ; BIOPSY ; ACID
英文摘要:

Objective

To assess the performance of self-assessment gastroesophageal reflux disease questionnaire (GerdQ), 24-h impedance monitoring, proton pump inhibitor (PPI) test and intercellular space of esophageal mucosal epithelial cells in the diagnosis of gastroesophageal reflux disease (GERD).

Methods

Patients with symptoms suspected of GERD were administered the GerdQ and underwent endoscopy (measurement of intercellular space in the biopsy specimen sampling at 2 cm above the Z-line) and 24-h impedance pH monitoring, together with a 2-week experimental treatment with esomeprazole.

Results

A total of 636 patients were included for the final analysis, including 352 with GERD. The sensitivity and specificity of GerdQ and 24-h impedance monitoring for diagnosing GERD were 57.7% and 48.9%, and 66.4% and 43.3%, respectively. The sensitivity of 24-h impedance pH monitoring increased to 93.7%. The sensitivity and specificity of dilated intercellular spaces (DIS) (>= 0.9 mu m) for diagnosing GERD were 61.2% and 56.1%, respectively, whereas those for PPI test were 70.5% and 44.4%.

Conclusions

GerdQ score or PPI test alone cannot accurately diagnose GERD in a Chinese population suspected of GERD. A definitive diagnosis of GERD still depends on endoscopy or 24-h pH monitoring. 24-h impedance pH monitoring may increase the sensitivity for diagnosing GERD by 20%; however, when used alone, it results in poor specificity in patients without acid suppressive therapy.

语种: 英语
WOS记录号: WOS:000334684800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57214
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Li Ya,Wang, Ye,Lu, Jing Jing,et al. Accuracy of diagnosing gastroesophageal reflux disease by GerdQ, esophageal impedance monitoring and histology[J]. JOURNAL OF DIGESTIVE DISEASES,2014,15(5):230-238.
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