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学科主题临床医学
Accuracy of diagnosing gastroesophageal reflux disease by GerdQ, esophageal impedance monitoring and histology
Zhou, Li Ya; Wang, Ye; Lu, Jing Jing; Lin, Lin; Cui, Rong Li; Zhang, He Jun; Xue, Yan; Ding, Shi Gang; Lin, San Ren
关键词Impedance Intercellular Space Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease Questionnaire
刊名JOURNAL OF DIGESTIVE DISEASES
2014-05-01
DOI10.1111/1751-2980.12135
15期:5页:230-238
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]NORMAL VALUES ; QUESTIONNAIRE ; MANAGEMENT ; EPIDEMIOLOGY ; VALIDATION ; ENDOSCOPY ; SYMPTOMS ; THERAPY ; BIOPSY ; ACID
英文摘要

Objective

To assess the performance of self-assessment gastroesophageal reflux disease questionnaire (GerdQ), 24-h impedance monitoring, proton pump inhibitor (PPI) test and intercellular space of esophageal mucosal epithelial cells in the diagnosis of gastroesophageal reflux disease (GERD).

Methods

Patients with symptoms suspected of GERD were administered the GerdQ and underwent endoscopy (measurement of intercellular space in the biopsy specimen sampling at 2 cm above the Z-line) and 24-h impedance pH monitoring, together with a 2-week experimental treatment with esomeprazole.

Results

A total of 636 patients were included for the final analysis, including 352 with GERD. The sensitivity and specificity of GerdQ and 24-h impedance monitoring for diagnosing GERD were 57.7% and 48.9%, and 66.4% and 43.3%, respectively. The sensitivity of 24-h impedance pH monitoring increased to 93.7%. The sensitivity and specificity of dilated intercellular spaces (DIS) (>= 0.9 mu m) for diagnosing GERD were 61.2% and 56.1%, respectively, whereas those for PPI test were 70.5% and 44.4%.

Conclusions

GerdQ score or PPI test alone cannot accurately diagnose GERD in a Chinese population suspected of GERD. A definitive diagnosis of GERD still depends on endoscopy or 24-h pH monitoring. 24-h impedance pH monitoring may increase the sensitivity for diagnosing GERD by 20%; however, when used alone, it results in poor specificity in patients without acid suppressive therapy.

语种英语
WOS记录号WOS:000334684800003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57214
专题北京大学第三临床医学院_消化科
北京大学精神卫生研究所_护理部
作者单位Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Li Ya,Wang, Ye,Lu, Jing Jing,et al. Accuracy of diagnosing gastroesophageal reflux disease by GerdQ, esophageal impedance monitoring and histology[J]. JOURNAL OF DIGESTIVE DISEASES,2014,15(5):230-238.
APA Zhou, Li Ya.,Wang, Ye.,Lu, Jing Jing.,Lin, Lin.,Cui, Rong Li.,...&Lin, San Ren.(2014).Accuracy of diagnosing gastroesophageal reflux disease by GerdQ, esophageal impedance monitoring and histology.JOURNAL OF DIGESTIVE DISEASES,15(5),230-238.
MLA Zhou, Li Ya,et al."Accuracy of diagnosing gastroesophageal reflux disease by GerdQ, esophageal impedance monitoring and histology".JOURNAL OF DIGESTIVE DISEASES 15.5(2014):230-238.
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