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学科主题口腔医学
YAP Overexpression Affects Tooth Morphogenesis and Enamel Knot Patterning
Liu, M.1; Zhao, S.1,2; Wang, X-P1
关键词Morphogenesis Dental Lamina Signaling Center Epithelial-mesenchymal Interaction Tooth Development Hippo Signaling
刊名JOURNAL OF DENTAL RESEARCH
2014-05-01
DOI10.1177/0022034514525784
93期:5页:469-474
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者The Harvard School of Dental Medicine Dean&prime ; s Scholar Award ; The Harvard School of Dental Medicine Dean&prime ; s Scholar Award
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]SIGNALING CENTER ; CONTACT INHIBITION ; ALPHA-CATENIN ; HIPPO PATHWAY ; MOUSE TOOTH ; STEM-CELLS ; PROLIFERATION ; GROWTH ; SIZE ; ODONTOGENESIS
英文摘要

Teeth develop through distinct morphological stages. At the cap stage, a compactly clustered and concentrically arranged cell mass, the enamel knot, appears at the tip of the enamel organ. Cells in this knot express sets of key molecules, and as such have been proposed to act as a signaling center directing tooth morphogenesis and tooth cusp formation. YAP is a transcriptional co-activator of the Hippo signaling pathway that is essential for the proper regulation of organ growth. In this study, we analyzed the tooth phenotype in transgenic mice that overexpressed a constitutively active form of YAP in the dental epithelium. We found that overexpression of YAP resulted in deformed tooth morphogenesis with widened dental lamina. In addition, the enamel knot was mislocated to the upper portion of the enamel organ, where it remained devoid of proliferating cells and contained apoptotic cells with intense Edar transcripts and reduced E-cadherin expression. Interestingly, some signaling molecules, such as Shh, Fgf4, and Wnt10a, were not expressed in this mislocated enamel knot, but remained at the tip of the enamel organ. Analysis of these data suggests that the signaling center is induced by reciprocal epithelial-mesenchymal interactions, and its induction may be independent of the enamel knot.

语种英语
资助者The Harvard School of Dental Medicine Dean&prime ; s Scholar Award ; The Harvard School of Dental Medicine Dean&prime ; s Scholar Award
WOS记录号WOS:000334265100006
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57217
专题北京大学口腔医学院_儿童口腔科
作者单位1.Harvard Univ, Sch Dent Med, Dept Dev Biol, Boston, MA 02115 USA
2.Peking Univ, Sch Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China
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Liu, M.,Zhao, S.,Wang, X-P. YAP Overexpression Affects Tooth Morphogenesis and Enamel Knot Patterning[J]. JOURNAL OF DENTAL RESEARCH,2014,93(5):469-474.
APA Liu, M.,Zhao, S.,&Wang, X-P.(2014).YAP Overexpression Affects Tooth Morphogenesis and Enamel Knot Patterning.JOURNAL OF DENTAL RESEARCH,93(5),469-474.
MLA Liu, M.,et al."YAP Overexpression Affects Tooth Morphogenesis and Enamel Knot Patterning".JOURNAL OF DENTAL RESEARCH 93.5(2014):469-474.
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