IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells
Zhang Yi1; Qian Rui-Qin1; Li Ping-Ping2
关键词Breast Cancer Steroid Sulfatase Estrogen Biosynthesis Shikonin In Vitro
刊名CANCER LETTERS
2009-10-18
DOI10.1016/j.canlet.2009.04.008
284期:1页:47-54
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]AROMATASE ACTIVITIES ; ESTRONE SULFATASE ; CARCINOMA-CELLS ; IN-VIVO ; PROLIFERATION ; THERAPY ; INHIBITORS ; GROWTH ; LINES ; ESTRADIOL
英文摘要

Steroid sulfatase (STS) has an important role in regulating the biosynthesis of estrogen within breast tumors. We aimed to investigate whether shikonin, an ingredient of Lithospermum erythrorhizon, could modulate STS expression in breast cancer cells. By MTT assay, shikonin inhibited the cell proliferation of breast cancer cells MCF-7 and SK-BR-3. Moreover, by semi-quantitative/quantitative reverse transcription polymerase chain reaction and dual-luciferase reporter based bioluminescent measurements, the mRNA and enzymatic activity levels of STS were decreased after shikonin treatment. Concluding. shikonin could act as a selective estrogen enzyme modulator by down-regulating the STS expression. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000270238400007
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57219
Collection北京大学基础医学院
北京大学临床肿瘤学院_中西医结合科暨老年肿瘤科
作者单位1.Peking Univ, Dept Integrated Tradit Chinese & Western Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Dept Integrated Tradit Chinese & Western Med, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Zhang Yi,Qian Rui-Qin,Li Ping-Ping. Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells[J]. CANCER LETTERS,2009,284(1):47-54.
APA Zhang Yi,Qian Rui-Qin,&Li Ping-Ping.(2009).Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells.CANCER LETTERS,284(1),47-54.
MLA Zhang Yi,et al."Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells".CANCER LETTERS 284.1(2009):47-54.
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