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学科主题: 基础医学
题名:
Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells
作者: Zhang Yi1; Qian Rui-Qin1; Li Ping-Ping2
关键词: Breast cancer ; Steroid sulfatase ; Estrogen biosynthesis ; Shikonin ; In vitro
刊名: CANCER LETTERS
发表日期: 2009-10-18
DOI: 10.1016/j.canlet.2009.04.008
卷: 284, 期:1, 页:47-54
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: AROMATASE ACTIVITIES ; ESTRONE SULFATASE ; CARCINOMA-CELLS ; IN-VIVO ; PROLIFERATION ; THERAPY ; INHIBITORS ; GROWTH ; LINES ; ESTRADIOL
英文摘要:

Steroid sulfatase (STS) has an important role in regulating the biosynthesis of estrogen within breast tumors. We aimed to investigate whether shikonin, an ingredient of Lithospermum erythrorhizon, could modulate STS expression in breast cancer cells. By MTT assay, shikonin inhibited the cell proliferation of breast cancer cells MCF-7 and SK-BR-3. Moreover, by semi-quantitative/quantitative reverse transcription polymerase chain reaction and dual-luciferase reporter based bioluminescent measurements, the mRNA and enzymatic activity levels of STS were decreased after shikonin treatment. Concluding. shikonin could act as a selective estrogen enzyme modulator by down-regulating the STS expression. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2004-IV15
项目资助者: The Key Program Foundation of Beijing Administration of Traditional Chinese Medicines, China
WOS记录号: WOS:000270238400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57219
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Integrated Tradit Chinese & Western Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Dept Integrated Tradit Chinese & Western Med, Beijing 100142, Peoples R China

Recommended Citation:
Zhang Yi,Qian Rui-Qin,Li Ping-Ping. Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells[J]. CANCER LETTERS,2009,284(1):47-54.
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