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Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells
Zhang Yi1; Qian Rui-Qin1; Li Ping-Ping2
关键词Breast Cancer Steroid Sulfatase Estrogen Biosynthesis Shikonin In Vitro
刊名CANCER LETTERS
2009-10-18
DOI10.1016/j.canlet.2009.04.008
284期:1页:47-54
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者The Key Program Foundation of Beijing Administration of Traditional Chinese Medicines, China ; The Key Program Foundation of Beijing Administration of Traditional Chinese Medicines, China
研究领域[WOS]Oncology
关键词[WOS]AROMATASE ACTIVITIES ; ESTRONE SULFATASE ; CARCINOMA-CELLS ; IN-VIVO ; PROLIFERATION ; THERAPY ; INHIBITORS ; GROWTH ; LINES ; ESTRADIOL
英文摘要

Steroid sulfatase (STS) has an important role in regulating the biosynthesis of estrogen within breast tumors. We aimed to investigate whether shikonin, an ingredient of Lithospermum erythrorhizon, could modulate STS expression in breast cancer cells. By MTT assay, shikonin inhibited the cell proliferation of breast cancer cells MCF-7 and SK-BR-3. Moreover, by semi-quantitative/quantitative reverse transcription polymerase chain reaction and dual-luciferase reporter based bioluminescent measurements, the mRNA and enzymatic activity levels of STS were decreased after shikonin treatment. Concluding. shikonin could act as a selective estrogen enzyme modulator by down-regulating the STS expression. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2004-IV15
资助者The Key Program Foundation of Beijing Administration of Traditional Chinese Medicines, China ; The Key Program Foundation of Beijing Administration of Traditional Chinese Medicines, China
WOS记录号WOS:000270238400007
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57219
专题基础医学院
作者单位1.Peking Univ, Dept Integrated Tradit Chinese & Western Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Dept Integrated Tradit Chinese & Western Med, Beijing 100142, Peoples R China
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GB/T 7714
Zhang Yi,Qian Rui-Qin,Li Ping-Ping. Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells[J]. CANCER LETTERS,2009,284(1):47-54.
APA Zhang Yi,Qian Rui-Qin,&Li Ping-Ping.(2009).Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells.CANCER LETTERS,284(1),47-54.
MLA Zhang Yi,et al."Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells".CANCER LETTERS 284.1(2009):47-54.
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