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学科主题: 临床医学
题名:
The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression
作者: Zhao, Na1,2,3,4; Hou, Ping1,2,3,4; Lv, Jicheng1,2,3,4; Moldoveanu, Zina5; Li, Yifu6; Kiryluk, Krzysztof6; Gharavi, Ali G.6; Novak, Jan5; Zhang, Hong1,2,3,4
关键词: galactose-deficient IgA1 ; IgA nephropathy ; kidney disease progression
刊名: KIDNEY INTERNATIONAL
发表日期: 2012-10-01
DOI: 10.1038/ki.2012.197
卷: 82, 期:7, 页:790-796
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ABERRANTLY GLYCOSYLATED IGA1 ; O-GLYCOSYLATION ; OXFORD CLASSIFICATION ; MESANGIAL CELLS ; IMMUNE-COMPLEXES ; ACE-INHIBITORS ; PATHOGENESIS ; TRIAL ; PROLIFERATION ; HETEROGENEITY
英文摘要:

Although high serum levels of galactose-deficient IgA1 (an important biomarker of IgA nephropathy (IgAN)) are found in most patients with IgAN, their relationship to disease severity and progression remains unclear. To help clarify this we prospectively enrolled 275 patients with IgAN and followed them for a median of 47 months (range 12-96 months). Serum galactose-deficient IgA1 was measured at the time of diagnosis using a lectin-based ELISA, and renal survival was modeled using the Cox proportional hazards method. The serum levels of galactose-deficient IgA1 were higher in patients with IgAN compared to those in healthy controls. Importantly, in adjusted analysis, higher levels of galactose-deficient IgA1 were independently associated with a greater risk of deterioration in renal function with a hazard ratio of 1.44 per standard deviation of the natural log-transformed galactose-deficient IgA1 concentration. In reference to the first quartile, the risk of kidney failure increased such that the hazard ratio for the second quartile was 2.47, 3.86 for the third, and 4.76 for the fourth quartile of the galactose-deficient IgA1 concentration. Hence, elevated serum levels of galactose-deficient IgA1 are associated with a poor prognosis in IgAN. Kidney International (2012) 82, 790-796; doi:10.1038/ki.2012.197; published online 6 June 2012

语种: 英语
所属项目编号: 30825021 ; 81021004 ; DK082753 ; DK078244 ; DK083663
项目资助者: National Natural Science Foundation for Distinguished Young Scholars of China ; Peking University First Hospital Clinical Research Funds ; National Natural Science Foundation for Innovative Research Groups of China ; National Institutes of Health, USA
WOS记录号: WOS:000308928600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57224
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Columbia Univ, Dept Med, Coll Phys & Surg, New York, NY USA
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
6.Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

Recommended Citation:
Zhao, Na,Hou, Ping,Lv, Jicheng,et al. The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression[J]. KIDNEY INTERNATIONAL,2012,82(7):790-796.
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