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学科主题临床医学
The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression
Zhao, Na1,2,3,4; Hou, Ping1,2,3,4; Lv, Jicheng1,2,3,4; Moldoveanu, Zina5; Li, Yifu6; Kiryluk, Krzysztof6; Gharavi, Ali G.6; Novak, Jan5; Zhang, Hong1,2,3,4
关键词Galactose-deficient Iga1 Iga Nephropathy Kidney Disease Progression
刊名KIDNEY INTERNATIONAL
2012-10-01
DOI10.1038/ki.2012.197
82期:7页:790-796
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者National Natural Science Foundation for Distinguished Young Scholars of China ; Peking University First Hospital Clinical Research Funds ; National Natural Science Foundation for Innovative Research Groups of China ; National Institutes of Health, USA ; National Natural Science Foundation for Distinguished Young Scholars of China ; Peking University First Hospital Clinical Research Funds ; National Natural Science Foundation for Innovative Research Groups of China ; National Institutes of Health, USA
研究领域[WOS]Urology & Nephrology
关键词[WOS]ABERRANTLY GLYCOSYLATED IGA1 ; O-GLYCOSYLATION ; OXFORD CLASSIFICATION ; MESANGIAL CELLS ; IMMUNE-COMPLEXES ; ACE-INHIBITORS ; PATHOGENESIS ; TRIAL ; PROLIFERATION ; HETEROGENEITY
英文摘要

Although high serum levels of galactose-deficient IgA1 (an important biomarker of IgA nephropathy (IgAN)) are found in most patients with IgAN, their relationship to disease severity and progression remains unclear. To help clarify this we prospectively enrolled 275 patients with IgAN and followed them for a median of 47 months (range 12-96 months). Serum galactose-deficient IgA1 was measured at the time of diagnosis using a lectin-based ELISA, and renal survival was modeled using the Cox proportional hazards method. The serum levels of galactose-deficient IgA1 were higher in patients with IgAN compared to those in healthy controls. Importantly, in adjusted analysis, higher levels of galactose-deficient IgA1 were independently associated with a greater risk of deterioration in renal function with a hazard ratio of 1.44 per standard deviation of the natural log-transformed galactose-deficient IgA1 concentration. In reference to the first quartile, the risk of kidney failure increased such that the hazard ratio for the second quartile was 2.47, 3.86 for the third, and 4.76 for the fourth quartile of the galactose-deficient IgA1 concentration. Hence, elevated serum levels of galactose-deficient IgA1 are associated with a poor prognosis in IgAN. Kidney International (2012) 82, 790-796; doi:10.1038/ki.2012.197; published online 6 June 2012

语种英语
所属项目编号30825021 ; 81021004 ; DK082753 ; DK078244 ; DK083663
资助者National Natural Science Foundation for Distinguished Young Scholars of China ; Peking University First Hospital Clinical Research Funds ; National Natural Science Foundation for Innovative Research Groups of China ; National Institutes of Health, USA ; National Natural Science Foundation for Distinguished Young Scholars of China ; Peking University First Hospital Clinical Research Funds ; National Natural Science Foundation for Innovative Research Groups of China ; National Institutes of Health, USA
WOS记录号WOS:000308928600008
Citation statistics
Cited Times:61[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57224
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Columbia Univ, Dept Med, Coll Phys & Surg, New York, NY USA
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
6.Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA
Recommended Citation
GB/T 7714
Zhao, Na,Hou, Ping,Lv, Jicheng,et al. The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression[J]. KIDNEY INTERNATIONAL,2012,82(7):790-796.
APA Zhao, Na.,Hou, Ping.,Lv, Jicheng.,Moldoveanu, Zina.,Li, Yifu.,...&Zhang, Hong.(2012).The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression.KIDNEY INTERNATIONAL,82(7),790-796.
MLA Zhao, Na,et al."The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression".KIDNEY INTERNATIONAL 82.7(2012):790-796.
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