北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Association of Epitope Spreading of Antiglomerular Basement Membrane Antibodies and Kidney Injury
作者: Chen, Jun-liang; Hu, Shui-yi; Jia, Xiao-yu; Zhao, Juan; Yang, Rui; Cui, Zhao1; Zhao, Ming-hui
刊名: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2013
DOI: 10.2215/CJN.05140512
卷: 8, 期:1, 页:51-58
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS ; ALPHA-3(IV) COLLAGEN CHAIN ; ANTI-GBM DISEASE ; T-CELL EPITOPE ; GOODPASTURE AUTOANTIGEN ; NC1 DOMAIN ; IV ; AUTOANTIBODIES ; IDENTIFICATION ; MECHANISM
英文摘要:

Background and objectives Antiglomerular basement membrane autoantibodies are pathogenic in antiglomerular basement membrane disease with two major epitopes, E-A and E-B, on alpha 3 chain of type IV collagen. This study investigated the epitope spectrum of antiglomerular basement membrane autoantibodies, aiming to identify the association between epitope specificity and kidney injury.

Design, setting, participants, & measurements All 108 patients with antiglomerular basement membrane disease and complete clinical data were divided into three groups according to renal dysfunction: mild group (n=20) with serum creatitine <= 1.5 mg/dl; moderate group (n=22) with serum creatinine=1.5-6.8 mg/dl; severe group (n=66) with serum creatitine >= 6.8 mg/dl. Epitope spectrums of antibodies were determined by ELISA, and their associations with kidney damage were analyzed. Sequential serum samples in 40 patients were examined during disease courses.

Results E-A and E-B were recognized in 79.6% and 72.2% of patients, respectively. E-A and E-B reactions were the lowest in the mild group and higher in the moderate group (E-A: 35.0% versus 81.8%, P=0.002; E-B: 15.0% versus 68.2%, P=0.001). They were the highest in the severe group (E-A: 92.4%, P=0.31; E-B: 90.9%, P=0.02). Close association was observed between renal injury and E-A and E-B reactions. Multivariate Cox regression analysis showed that E-B reaction was an independent risk factor for renal failure (hazard ratio=6.91, P=0.02). The recognition for non-E-AB remained low among groups. No augmentation of epitope spectrum was shown in serial serum samples.

Conclusions Intramolecular epitope spreading might occur before the onset of human antiglomerular basement membrane disease. The autoimmunity to E-A and E-B, especially E-B, was crucial for kidney dysfunction. Clin J Am Soc Nephrol 8: 51-58, 2013. doi: 10.2215/CJN.05140512

语种: 英语
所属项目编号: 2012CB517702 ; 81021004 ; 81170645
项目资助者: Chinese 973 Project ; National Natural Science Fund of China
WOS记录号: WOS:000313221500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57225
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Minist Hlth China, Inst Nephrol,Key Lab Renal Dis,Dept Med,Renal Div, Beijing 100034, Peoples R China
3.Peking Univ, Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Jun-liang,Hu, Shui-yi,Jia, Xiao-yu,et al. Association of Epitope Spreading of Antiglomerular Basement Membrane Antibodies and Kidney Injury[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2013,8(1):51-58.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Jun-liang]'s Articles
[Hu, Shui-yi]'s Articles
[Jia, Xiao-yu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Jun-liang]‘s Articles
[Hu, Shui-yi]‘s Articles
[Jia, Xiao-yu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace