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学科主题药学
RGD-based strategies for improving antitumor activity of paclitaxel-loaded liposomes in nude mice xenografted with human ovarian cancer
Zhao, Hui1,2; Wang, Jian-Cheng1; Sun, Qi-Shi2; Luo, Chun-Lei1; Zhang, Qiang1,3
关键词Rgd Peptide Targeting Liposomes Paclitaxel Antitumor
刊名JOURNAL OF DRUG TARGETING
2009
DOI10.1080/10611860802368966
17期:1页:10-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]STERICALLY STABILIZED LIPOSOMES ; TAXOL-CONTAINING LIPOSOMES ; IN-VIVO ; INTRACELLULAR DELIVERY ; CELL-ADHESION ; DOXORUBICIN ; INTEGRINS ; EFFICACY ; FORMULATIONS ; THERAPY
英文摘要

Tumor-targeting drug delivery systems are being the ideal carrier for systemic administration of antiproliferative drugs. RGD peptide (arginine-glycine-aspartic acid) modified liposomes containing paclitaxel (RGD-SSL-PTX). The arginine-glycineaspartic acid tripeptide (RGD) modified sterically stabilized liposomes (SSL) containing paclitaxel (PTX) (RGD-SSL-PTX), which could increase targeting to tumor by binding with the integrin receptors overexpressed on tumor cells. The encapsulation efficiency was more than 90% and the mean particle size was of 120nm with a narrow size distribution. It was indicated that significant cytotoxicity (3.5 times lower IC(50)) was found in the SKOV-3 human ovarian cancer cells treated with RGD-SSL-PTX preparation, as well as the intracellular uptake of liposomes (a 6.21-fold increase in fluorescence intensity), when compared to those of non-targeted liposomes (SSL). For in vivo antitumor activity, it was shown in the present study thatRGD-SSL-PTX preparation had the strongest tumor growth inhibition among the test formulations (P < 0.05) in BALB/c nude mice xenografted with SKOV-3 solid tumor. Meanwhile, there was no significant change in the body weight of the animals treated with RGD-SSL-PTX for intravenous injection at a dose of 12.5 mg/kg. It was suggested that the RGD-SSL-PTX preparation might have a great advantage over present-day chemotherapy with Taxol (R) in curing those tumors overexpressing integrin receptors.

语种英语
WOS记录号WOS:000261943900002
Citation statistics
Cited Times:59[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57230
Collection北京大学药学院_药剂学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Dept Tradit Chinese Med, Shenyang 110015, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Hui,Wang, Jian-Cheng,Sun, Qi-Shi,et al. RGD-based strategies for improving antitumor activity of paclitaxel-loaded liposomes in nude mice xenografted with human ovarian cancer[J]. JOURNAL OF DRUG TARGETING,2009,17(1):10-18.
APA Zhao, Hui,Wang, Jian-Cheng,Sun, Qi-Shi,Luo, Chun-Lei,&Zhang, Qiang.(2009).RGD-based strategies for improving antitumor activity of paclitaxel-loaded liposomes in nude mice xenografted with human ovarian cancer.JOURNAL OF DRUG TARGETING,17(1),10-18.
MLA Zhao, Hui,et al."RGD-based strategies for improving antitumor activity of paclitaxel-loaded liposomes in nude mice xenografted with human ovarian cancer".JOURNAL OF DRUG TARGETING 17.1(2009):10-18.
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