IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI
Zhang, Yudong1; Wang, Jing1,2; Yang, Xuedong1; Wang, Xiaoying1; Zhang, Jue2,3; Fang, Jing2,3; Jiang, Xuexiang1
关键词Mri Arterial Spin-labeling Blood Oxygen Level-dependent Contrast-induced Nephropathy Oxygenation Perfusion
刊名CONTRAST MEDIA & MOLECULAR IMAGING
2012-07-01
DOI10.1002/cmmi.1468
7期:4页:418-425
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]INDUCED NEPHROPATHY ; INTRARENAL OXYGENATION ; RAT-KIDNEY ; BLOOD-FLOW ; RISK-FACTORS ; PERFUSION ; RADIOCONTRAST ; INSUFFICIENCY ; VASOCONSTRICTION ; DEFINITION
英文摘要

Contrast-induced nephropathy is a prevalent cause of renal failure, and the mechanisms underlying this injury are not fully understood. We utilized noninvasive functional MRI in order to determine the serial effect of a single administration of iodinated contrast media (CM) on renal hemodynamics and oxygenation. Fifteen rabbits were randomized to receive an intravenous injection of CM (i.e. iopamidol-370; 6?ml?kg-1 body weight) or an equivalent amount of 0.9% saline. Both arterial spin-labeling and blood oxygen level-dependent imaging sequences were performed at 24?h before and at intervals of 1, 24, 48 and 72?h after injection to obtain serial renal blood flow (RBF) and relative spinspin relaxation rate (R2*). Results showed that, in the iopamidol group, the mean cortical RBF decreased at 1?h (p?=?0.04 vs baseline), reached its minimum at 24?h (p?=?0.01) and gradually returned to baseline by 48?h (p?=?nonsignificant, NS). The outer medullary RBF decreased to its minimum by 24?h (p?=?0.00) and remained less than baseline until 72?h. R2* in inner stripes was dramatically increased at 1?h (p?=?0.00), remained elevated at 24?h (p?=?0.05), but returned to baseline by 48?h (p?=?NS). R2* values within the cortex and outer stripes and inner medulla were slightly increased, but the changes did not reach a statistical significance (p?=?NS). Saline did not produce positive change in either RBF or R2* within different compartments of the kidney. We conclude that iopamidol is associated with a relatively longer-term hypoperfusion in whole kidney and decreased oxygen level in the inner stripes of the outer medulla. Copyright (c) 2012 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000304665100008
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57231
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yudong,Wang, Jing,Yang, Xuedong,et al. The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI[J]. CONTRAST MEDIA & MOLECULAR IMAGING,2012,7(4):418-425.
APA Zhang, Yudong.,Wang, Jing.,Yang, Xuedong.,Wang, Xiaoying.,Zhang, Jue.,...&Jiang, Xuexiang.(2012).The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI.CONTRAST MEDIA & MOLECULAR IMAGING,7(4),418-425.
MLA Zhang, Yudong,et al."The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI".CONTRAST MEDIA & MOLECULAR IMAGING 7.4(2012):418-425.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Yudong]的文章
[Wang, Jing]的文章
[Yang, Xuedong]的文章
百度学术
百度学术中相似的文章
[Zhang, Yudong]的文章
[Wang, Jing]的文章
[Yang, Xuedong]的文章
必应学术
必应学术中相似的文章
[Zhang, Yudong]的文章
[Wang, Jing]的文章
[Yang, Xuedong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。