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学科主题: 临床医学
题名:
ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage
作者: Shu, J; Zhu, TG; Yang, L; Cui, CC; Yan, GX
关键词: early repolarization syndrome ; idiopathic ventricular fibrillation ; Brugada syndrome
刊名: JOURNAL OF ELECTROCARDIOLOGY
发表日期: 2005-10-01
DOI: 10.1016/j.jelectrocard.2005.06.006
卷: suppl.S, 期:4, 页:26-32
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: SUDDEN CARDIAC DEATH ; ACUTE MYOCARDIAL-ISCHEMIA ; SODIUM-CHANNEL BLOCKERS ; BUNDLE-BRANCH BLOCK ; INTRACELLULAR-RECORDINGS ; T-WAVE ; INFERIOR ; MECHANISMS ; LEADS ; DURATION
英文摘要:

ST-segment elevation in a structurally normal heart is associated with an electrocardiographic (ECG) J wave, which can be observed in the early repolarization syndrome (ERS), idiopathic ventricular fibrillation (VF), and the Brugada syndrome. Animal studies have demonstrated that the J wave is the consequence of a transmural voltage gradient resulting from an I-to-mediated action potential notch (spike and dome) in epicardium but not endocardium. I-to-mediated spike and dome morphology predisposes loss or depression of the dome in epicardium, leading to ST-segment elevation. Despite the fact that 3 clinical syndromes share many common ECG features, their clinical consequences are remarkably different. The ERS is a benign ECG finding characterized by a distinct J wave and ST segment in left precordial leads V-4 through V-6. In contrast, idiopathic VF and the Brugada syndrome, characterized by a J wave and ST-segment elevation in the inferior and right precordial leads, respectively, are the leading causes for sudden cardiac death in young Southeast Asian males. The underlying mechanism for such a difference in clinical consequences among these syndromes is due to a difference in I-to density and I-to-mediated epicardial spike and dome. When I-to is prominent, complete loss of the dome may occur due to either a decrease in inward currents or an increase in outward currents, leading to phase 2 reentry capable of initiating VF as in idiopathic VF and the Brugada syndrome. When I-to is relatively small as in the ERS, partial depression of the dome occurs without the development of phase 2 reentry. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000233191000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57235
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Main Line Hlth Heart Ctr, Wynnewood, PA 19096 USA
2.Xian Jiaotong Univ, Hosp 1, Dept Cardiol, Xian 710061, Shaanxi, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Shu, J,Zhu, TG,Yang, L,et al. ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage[J]. JOURNAL OF ELECTROCARDIOLOGY,2005,suppl.S(4):26-32.
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