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The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis
Hao, Jian1,2,3,4,5,6; Wang, Chen1,2,3,4,5; Gou, Shen-ju1,2,3,4,5; Zhao, Ming-Hui1,2,3,4,5; Chen, Min1,2,3,4,5
关键词Plasminogen Antibodies Anca Vasculitis
刊名RHEUMATOLOGY
2014-02-01
DOI10.1093/rheumatology/ket345
53期:2页:300-306
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; SYSTEMIC VASCULITIS ; RENAL HISTOLOGY ; GLOMERULONEPHRITIS ; COMPLEMENTARY ; PROTEINASE-3 ; INJURY
英文摘要

Objective. Previous studies have shown that in patients with ANCA-associated vasculitis (AAV), anti-plasminogen antibodies were associated with reduced renal function and the presence of fibrinoid necrosis and cellular crescents in renal histology. The purpose of the current study was to investigate whether anti-plasminogen antibodies are associated with the systemic disease activity of AAV.

Methods. One hundred and four Chinese patients with AAV were recruited. Anti-plasminogen antibodies were detected in sequential serum samples at initial onset and remission of the disease. Associations of anti-plasminogen antibodies with clinicopathological parameters were analysed.

Results. The prevalence of anti-plasminogen antibodies was significantly higher in AAV patients than in healthy controls (19/104 vs 0/50, chi(2) = 8.8, P = 0.003). The prevalence of anti-plasminogen antibodies was significantly higher in the active stage of AAV than in remission (19/104 vs 1/48, chi(2) = 7.5, P = 0.013). The level of anti-plasminogen antibodies (expressed as a percentage of the positive controls) correlated with the ESR (r = 0.207, P = 0.042), serum creatinine (r = 0.302, P = 0.002), d-dimer (r = 0.273, P = 0.009) and the percentage of glomeruli with crescents in renal specimens (r = 0.393, P = 0.004). The level of Birmingham vasculitis activity scores and the prevalence of arthralgia and gastrointestinal involvement in patients with anti-plasminogen antibodies were significantly higher than in patients without anti-plasminogen antibodies [22.5 (s.d. 5.63) vs. 19.4 (s.d. 4.66), P = 0.015; 63.2% vs. 25.8%, P = 0.002; 57.9% vs. 21.1%, P = 0.001, respectively].

Conclusion. Circulating anti-plasminogen antibodies were associated with systemic disease activity and renal disease activity of AAV.

语种英语
WOS记录号WOS:000330434700015
项目编号2012CB517702 ; 20120001110018 ; 2011BAI10B04 ; 81021004
资助机构Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; &prime ; National Key Technology Research and Development (R&amp ; D) Program&prime ; of the Ministry of Science and Technology of China ; National Natural Science Fund
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57237
专题北京大学第一临床医学院_肾脏内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
3.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
6.Inner Mongolia Med Univ, Affiliated Hosp, Dept Med, Div Renal, Hohhot, Inner Mongolia, Peoples R China
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GB/T 7714
Hao, Jian,Wang, Chen,Gou, Shen-ju,et al. The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis[J]. RHEUMATOLOGY,2014,53(2):300-306.
APA Hao, Jian,Wang, Chen,Gou, Shen-ju,Zhao, Ming-Hui,&Chen, Min.(2014).The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis.RHEUMATOLOGY,53(2),300-306.
MLA Hao, Jian,et al."The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis".RHEUMATOLOGY 53.2(2014):300-306.
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