|The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis|
|Hao, Jian1,2,3,4,5,6; Wang, Chen1,2,3,4,5; Gou, Shen-ju1,2,3,4,5; Zhao, Ming-Hui1,2,3,4,5; Chen, Min1,2,3,4,5|
|关键词||Plasminogen Antibodies Anca Vasculitis|
|WOS标题词||Science & Technology|
|关键词[WOS]||ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; SYSTEMIC VASCULITIS ; RENAL HISTOLOGY ; GLOMERULONEPHRITIS ; COMPLEMENTARY ; PROTEINASE-3 ; INJURY|
Objective. Previous studies have shown that in patients with ANCA-associated vasculitis (AAV), anti-plasminogen antibodies were associated with reduced renal function and the presence of fibrinoid necrosis and cellular crescents in renal histology. The purpose of the current study was to investigate whether anti-plasminogen antibodies are associated with the systemic disease activity of AAV.
Methods. One hundred and four Chinese patients with AAV were recruited. Anti-plasminogen antibodies were detected in sequential serum samples at initial onset and remission of the disease. Associations of anti-plasminogen antibodies with clinicopathological parameters were analysed.
Results. The prevalence of anti-plasminogen antibodies was significantly higher in AAV patients than in healthy controls (19/104 vs 0/50, chi(2) = 8.8, P = 0.003). The prevalence of anti-plasminogen antibodies was significantly higher in the active stage of AAV than in remission (19/104 vs 1/48, chi(2) = 7.5, P = 0.013). The level of anti-plasminogen antibodies (expressed as a percentage of the positive controls) correlated with the ESR (r = 0.207, P = 0.042), serum creatinine (r = 0.302, P = 0.002), d-dimer (r = 0.273, P = 0.009) and the percentage of glomeruli with crescents in renal specimens (r = 0.393, P = 0.004). The level of Birmingham vasculitis activity scores and the prevalence of arthralgia and gastrointestinal involvement in patients with anti-plasminogen antibodies were significantly higher than in patients without anti-plasminogen antibodies [22.5 (s.d. 5.63) vs. 19.4 (s.d. 4.66), P = 0.015; 63.2% vs. 25.8%, P = 0.002; 57.9% vs. 21.1%, P = 0.001, respectively].
Conclusion. Circulating anti-plasminogen antibodies were associated with systemic disease activity and renal disease activity of AAV.
|项目编号||2012CB517702 ; 20120001110018 ; 2011BAI10B04 ; 81021004|
|资助机构||Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; &prime ; National Key Technology Research and Development (R& ; D) Program&prime ; of the Ministry of Science and Technology of China ; National Natural Science Fund|
|作者单位||1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China|
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
3.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
6.Inner Mongolia Med Univ, Affiliated Hosp, Dept Med, Div Renal, Hohhot, Inner Mongolia, Peoples R China
|Hao, Jian,Wang, Chen,Gou, Shen-ju,et al. The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis[J]. RHEUMATOLOGY,2014,53(2):300-306.|
|APA||Hao, Jian,Wang, Chen,Gou, Shen-ju,Zhao, Ming-Hui,&Chen, Min.(2014).The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis.RHEUMATOLOGY,53(2),300-306.|
|MLA||Hao, Jian,et al."The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis".RHEUMATOLOGY 53.2(2014):300-306.|