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学科主题: 药学
题名:
Identification of Echinacoside Metabolites Produced by Human Intestinal Bacteria Using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry
作者: Li, Yang1; Zhou, Guisheng1; Xing, Shihua1; Tu, Pengfei2; Li, Xiaobo1
关键词: echinacoside ; human intestinal bacteria ; UPLC-Q-TOF-MS ; metabolites ; metabolic pathway
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
发表日期: 2015-08-05
DOI: 10.1021/acs.jafc.5b02881
卷: 63, 期:30, 页:6764-6771
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]: Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]: FECAL MICROBIAL-METABOLISM ; IN-VITRO ; ANTIOXIDANT ACTIVITY ; PHENYLETHANOID GLYCOSIDES ; CAFFEIC ACID ; BIOLOGICAL-ACTIVITIES ; PARKINSONS-DISEASE ; CISTANCHE-TUBULOSA ; PHENOLIC-COMPOUNDS ; ROOT EXTRACT
英文摘要:

Echinacoside (ECH) is one of the representative phenylethanoid glycosides. It is widely present in plants and exhibits various bioactivities. However, the extremely low oral bioavailability of ECH in rats implies that ECH may go through multiple hydrolysis steps in the gastrointestinal tract prior to its absorption into the blood. Therefore, the gastrointestinal metabolites of ECH are more likely to be the bioactive components. This study established an approach combining ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) with MSE technology and MetaboLynx software for rapid analysis of the ECH metabolic profile produced by human intestinal bacteria. As a result, 13 ECH metabolites and 5 possible metabolic pathways (including deglycosylation, dehydroxylation, reduction, hydroxylation, and acetylation) were identified. Furthermore, hydroxytyrosol (HT) and 3-hydroxyphenylpropionic acid (3-HPP) were found to be the two bioactive metabolites of ECH produced by human intestinal bacteria.

语种: 英语
WOS记录号: WOS:000359279300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57238
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Li, Yang,Zhou, Guisheng,Xing, Shihua,et al. Identification of Echinacoside Metabolites Produced by Human Intestinal Bacteria Using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2015,63(30):6764-6771.
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