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学科主题: 临床医学
题名:
Impact of Baseline BMI on Glycemic Control and Weight Change with Metformin Monotherapy in Chinese Type 2 Diabetes Patients: Phase IV Open-Label Trial
作者: Ji, Linong1; Li, Hongmei2; Guo, Xiaohui3; Li, Yan4; Hu, Renming5; Zhu, Zhengying6
刊名: PLOS ONE
发表日期: 2013-02-28
DOI: 10.1371/journal.pone.0057222
卷: 8, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BODY-MASS INDEX ; NONOBESE PATIENTS ; RISK-FACTORS ; THERAPY ; HYPERGLYCEMIA ; MELLITUS ; EFFICACY ; ADULTS
英文摘要:

Background: Differences exist between treatment recommendations regarding the choice of metformin as first-line therapy for type 2 diabetes patients according to body mass index (BMI). This study compared the efficacy of metformin monotherapy among normal-weight, overweight, and obese patients with newly diagnosed type 2 diabetes.

Methods: In this prospective, multicenter, open-label study in China, patients aged 23-77 years were enrolled 1: 1: 1 according to baseline BMI: normal-weight (BMI 18.5-23.9 kg/m(2); n = 125); overweight (BMI 24.0-27.9 kg/m(2); n = 122) or obese (BMI >= 28 kg/m(2); n = 124). Extended-release metformin was administered for 16 weeks (500 mg/day, up-titrated weekly to a maximum 2,000 mg/day). The primary efficacy endpoint was the effect of baseline BMI on glycemic control with metformin monotherapy, measured as the change from baseline in glycosylated hemoglobin (HbA(1c)) at week 16 compared among BMI groups using ANCOVA. Other endpoints included comparisons of metformin′s effects on fasting plasma glucose (FPG), lipid levels and body weight.

Results: Mean HbA1c decreases at week 16, adjusted for baseline values, were -1.84%, -1.78% and -1.78% in normal-weight, overweight and obese patients, (P = 0.664); body weight decreased by 2.4%, 3.9% and 3.5%, respectively. FPG levels decreased similarly over time in all BMI groups (P = 0.461) and changes from baseline in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) did not differ significantly among BMI groups at week 16 (P = 0.143 and 0.451, respectively).

Conclusions: Baseline BMI had no impact on glycemic control, weight change or other efficacy measures with metformin monotherapy. These data suggest that normal-weight type 2 diabetes patients would derive the same benefits from first-line treatment with metformin as overweight and obese patients, and are not at increased risk of excess weight loss.

语种: 英语
项目资助者: Bristol-Myers Squibb
WOS记录号: WOS:000315524900060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57239
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
2.Sino Amer Shanghai Squibb Pharmaceut Ltd, Clin Res, China Res & Dev, Shanghai, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
4.Sun Yat Sen Univ, Dept Endocrinol, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
5.Fudan Univ, Huashan Hosp, Dept Endocrinol & Metab, Shanghai 200433, Peoples R China
6.Bristol Myers Squibb, China Res & Dev, Clin Res, Shanghai, Peoples R China

Recommended Citation:
Ji, Linong,Li, Hongmei,Guo, Xiaohui,et al. Impact of Baseline BMI on Glycemic Control and Weight Change with Metformin Monotherapy in Chinese Type 2 Diabetes Patients: Phase IV Open-Label Trial[J]. PLOS ONE,2013,8(2).
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