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Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities
Zhang, Yong1,2; Jiang, Peixin1,2; Ye, Min3; Kim, Sung-Hoon4; Jiang, Cheng1,2; Lu, Junxuan1,2
关键词Tanshinones Sources Pharmacokinetic Anti-cancer
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2012-10-01
DOI10.3390/ijms131013621
13期:10页:13621-13666
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]SALVIA-MILTIORRHIZA-BUNGE ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; PROSTATE-CANCER CELLS ; COUNTER-CURRENT CHROMATOGRAPHY ; HUMAN BREAST-CANCER ; HEPATOCELLULAR-CARCINOMA CELLS ; SOLID LIPID NANOPARTICLES ; TANDEM MASS-SPECTROMETRY ; MINOR-GROOVE-BINDING ; RNA-POLYMERASE-II
英文摘要

Tanshinones are a class of abietane diterpene compound isolated from Salvia miltiorrhiza (Danshen or Tanshen in Chinese), a well-known herb in Traditional Chinese Medicine (TCM). Since they were first identified in the 1930s, more than 40 lipophilic tanshinones and structurally related compounds have been isolated from Danshen. In recent decades, numerous studies have been conducted to investigate the isolation, identification, synthesis and pharmacology of tanshinones. In addition to the well-studied cardiovascular activities, tanshinones have been investigated more recently for their anti-cancer activities in vitro and in vivo. In this review, we update the herbal and alternative sources of tanshinones, and the pharmacokinetics of selected tanshinones. We discuss anti-cancer properties and identify critical issues for future research. Whereas previous studies have suggested anti-cancer potential of tanshinones affecting multiple cellular processes and molecular targets in cell culture models, data from in vivo potency assessment experiments in preclinical models vary greatly due to lack of uniformity of solvent vehicles and routes of administration. Chemical modifications and novel formulations had been made to address the poor oral bioavailability of tanshinones. So far, human clinical trials have been far from ideal in their design and execution for the purpose of supporting an anti-cancer indication of tanshinones.

语种英语
WOS记录号WOS:000310677800083
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57241
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, Dept Biomed Sci, Amarillo, TX 79106 USA
2.Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, Canc Biol Ctr, Amarillo, TX 79106 USA
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
4.Kyung Hee Univ, Canc Prevent Mat Dev Res Ctr, Coll Oriental Med, Seoul 130701, South Korea
推荐引用方式
GB/T 7714
Zhang, Yong,Jiang, Peixin,Ye, Min,et al. Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(10):13621-13666.
APA Zhang, Yong,Jiang, Peixin,Ye, Min,Kim, Sung-Hoon,Jiang, Cheng,&Lu, Junxuan.(2012).Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,13(10),13621-13666.
MLA Zhang, Yong,et al."Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13.10(2012):13621-13666.
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