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学科主题基础医学
BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer
Li, YY; Dong, XY; Yin, YH; Su, YR; Xu, OW; Zhang, YX; Pang, XW; Zhang, Y; Chen, WF
关键词biomarker BJ-TSA-9 lung cancer micrometastasis tumor-specific gene
刊名NEOPLASIA
2005-12-01
DOI10.1593/neo.05406
7期:12页:1073-1080
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]POLYMERASE-CHAIN-REACTION ; SQUAMOUS-CELL CARCINOMA ; RT-PCR AMPLIFICATION ; PERIPHERAL-BLOOD ; REVERSE-TRANSCRIPTASE ; MOLECULAR-DETECTION ; MESSENGER-RNA ; BREAST-CANCER ; HEPATOCELLULAR-CARCINOMA ; MELANOMA-CELLS
英文摘要

Using bioinformatics, we have identified a novel tumor-specific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (68.8%). To explore the potential application of BJ-TSA-9 for the detection of circulating cancer cells in lung cancer patients, nested RT-PCR was performed. The overall positive detection rate was 34.3% (24 of 70) in peripheral blood mononuclear cells (PBMCs) of patients with various types of lung cancers and was 53.6% (15 of 28) in PBMCs of lung adenocarcinoma patients. In combination with the detection of two known marker genes SCC and LUNX, the detection rate was increased to 81.4%. A follow-up study was performed in 37 patients after surgical removal of tumor mass. Among nine patients with persistent detection of two to three tumor marker transcripts in PBMCs, six patients had recurrence/metastasis. In contrast, 28 patients with transient detection of one tumor marker or without detection of any tumor marker were all in remission. Thus, BJ-TSA-9 may serve as a marker for lung cancer diagnosis and as a marker, in combination with two other tumor markers, for the prediction of the recurrence and prognosis of lung cancer patients.

语种英语
WOS记录号WOS:000234460100006
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57248
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Li, YY,Dong, XY,Yin, YH,et al. BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer[J]. NEOPLASIA,2005,7(12):1073-1080.
APA Li, YY.,Dong, XY.,Yin, YH.,Su, YR.,Xu, OW.,...&Chen, WF.(2005).BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer.NEOPLASIA,7(12),1073-1080.
MLA Li, YY,et al."BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer".NEOPLASIA 7.12(2005):1073-1080.
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