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学科主题: 基础医学
题名:
BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer
作者: Li, YY; Dong, XY; Yin, YH; Su, YR; Xu, OW; Zhang, YX; Pang, XW; Zhang, Y; Chen, WF
关键词: biomarker ; BJ-TSA-9 ; lung cancer ; micrometastasis ; tumor-specific gene
刊名: NEOPLASIA
发表日期: 2005-12-01
DOI: 10.1593/neo.05406
卷: 7, 期:12, 页:1073-1080
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: POLYMERASE-CHAIN-REACTION ; SQUAMOUS-CELL CARCINOMA ; RT-PCR AMPLIFICATION ; PERIPHERAL-BLOOD ; REVERSE-TRANSCRIPTASE ; MOLECULAR-DETECTION ; MESSENGER-RNA ; BREAST-CANCER ; HEPATOCELLULAR-CARCINOMA ; MELANOMA-CELLS
英文摘要:

Using bioinformatics, we have identified a novel tumor-specific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (68.8%). To explore the potential application of BJ-TSA-9 for the detection of circulating cancer cells in lung cancer patients, nested RT-PCR was performed. The overall positive detection rate was 34.3% (24 of 70) in peripheral blood mononuclear cells (PBMCs) of patients with various types of lung cancers and was 53.6% (15 of 28) in PBMCs of lung adenocarcinoma patients. In combination with the detection of two known marker genes SCC and LUNX, the detection rate was increased to 81.4%. A follow-up study was performed in 37 patients after surgical removal of tumor mass. Among nine patients with persistent detection of two to three tumor marker transcripts in PBMCs, six patients had recurrence/metastasis. In contrast, 28 patients with transient detection of one tumor marker or without detection of any tumor marker were all in remission. Thus, BJ-TSA-9 may serve as a marker for lung cancer diagnosis and as a marker, in combination with two other tumor markers, for the prediction of the recurrence and prognosis of lung cancer patients.

语种: 英语
WOS记录号: WOS:000234460100006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57248
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Li, YY,Dong, XY,Yin, YH,et al. BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer[J]. NEOPLASIA,2005,7(12):1073-1080.
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