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学科主题: 药学
题名:
Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry
作者: Han, Jian; Ye, Min; Xu, Man; Sun, Jianghao; Wang, Baorong; Guo, Dean
关键词: Huangqin ; flavonoids ; HPLC/DAD/ESI-MSn ; Chinese medicine
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2007-04-01
DOI: 10.1016/j.jchromb.2006.10.061
卷: 848, 期:2, 页:355-362
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: SCUTELLARIA-BAICALENSIS-GEORGI ; FAST-ATOM-BOMBARDMENT ; O-GLYCOSIDES ; IDENTIFICATION ; DISSOCIATION ; ASSIGNMENT ; SCAN
英文摘要:

The root of Scutellaria baicalensis, called Huangqin in Chinese, is one of the most commonly used traditional Chinese medicines for the treatment of hepatitis. tumors, diarrhea, and inflammatory diseases. The major chemical constituents of Huangqin are flavonoids. In the present paper, HPLC-DAD-ESI-MSn was used to analyze flavonoids in the roots of S. baicalensis. A total of 26 flavonoids were identified or tentatively characterized. including 5 C-glycosides, 12 O-glycosides, and 9 free aglycones. Two C-glycosides, apigenin-6-C-glucyl-8-C-arabinoside and chrysin-6.8-di-C-glucoside, together with some O-glycosides, are reported from S. baicalensis for the first time. This method is simple, reliable and sensitive. and could be used for the quality control of Huangqin and its related preparations. (c) 2006 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000245762600025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57250
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Han, Jian,Ye, Min,Xu, Man,et al. Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,848(2):355-362.
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