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Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design
Hao, Jifu1,2; Wang, Fugang2; Wang, Xiaodan2; Zhang, Dianrui1; Bi, Yanping2; Gao, Yunsheng2; Zhao, Xuemei2; Zhang, Qiang3
关键词Baicalin Coacervation Method Central Composite Design Solid Lipid Nanoparticle
刊名EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2012-09-29
DOI10.1016/j.ejps.2012.07.006
47期:2页:497-505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Nature Science Foundation of China ; Program from the National Basic Research of China ; National Nature Science Foundation of China ; Program from the National Basic Research of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]OPTIMAL MIXTURE DESIGN ; IN-VIVO ; CYCLOSPORINE-A ; DRUG-DELIVERY ; SLN ; PHARMACOKINETICS ; BIOAVAILABILITY ; CYTOTOXICITY ; FORMULATION ; ABSORPTION
英文摘要

The objective of this study was to design and optimize a novel baicalin-loaded solid lipid nanoparticles (SLNs) carrier system composed of a stearic acid alkaline salt as lipid matrix and prepared as per the coacervation method in which fatty acids precipitated from their sodium salt micelles in the presence of polymeric nonionic surfactants. A two-factor five-level central composite design (CCD) was introduced to perform the experiments. A quadratic polynomial model was generated to predict and evaluate the independent variables with respect to the dependent variables. The composition of optimal formulation was determined as 0.69% (w/v) lipid and 26.64% (w/w) drug/lipid ratio. The results showed that the optimal formulation of baicalin-loaded SLN had entrapment efficiency (EE) of 88.29%, particle size of 347.3 nm and polydispersity index (PDI) of 0.169. The morphology of nanoparticles was found to be nearly spherical in shape by scanning electron microscopy (SEM) observation. The differential scanning calorimetry (DSC) analysis indicated that the drug incorporated into SLN was not in an amorphous form but in a crystalline state. The C-max MRT, AUMC(0 ->infinity) and AUC(0 ->infinity) values of SLN were approximately 1.6-fold, 1.9-fold, 5.0-fold and 2.6-fold greater than that of reference preparation, respectively. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
所属项目编号81102820 ; 2009CB930300
资助者National Nature Science Foundation of China ; Program from the National Basic Research of China ; National Nature Science Foundation of China ; Program from the National Basic Research of China
WOS记录号WOS:000309029400025
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57255
专题北京大学药学院
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Taishan Med Univ, Coll Pharm, Tai An 271016, Shandong, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Hao, Jifu,Wang, Fugang,Wang, Xiaodan,et al. Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2012,47(2):497-505.
APA Hao, Jifu.,Wang, Fugang.,Wang, Xiaodan.,Zhang, Dianrui.,Bi, Yanping.,...&Zhang, Qiang.(2012).Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,47(2),497-505.
MLA Hao, Jifu,et al."Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 47.2(2012):497-505.
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