|Polymorphism K469E of intercellular adhesion molecule-1 gene and restenosis after coronary stenting in Chinese patients|
|Liu, ZP; Huo, Y; Li, JP; Zhang, Y; Xue, L; Zhao, CY; Hong, XM; Huang, AQ; Gao, W|
|关键词||Coronary Diseases Intercellular Adhesion Molecule-1 Gene Polymorphism Stents Restenosis|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||MYOCARDIAL-INFARCTION ; WEIGHT-LOSS ; RISK FACTOR ; DISEASE ; INFLAMMATION ; WOMEN|
Background Inflammation is a major cause of restenosis after coronary stenting. Intercellular adhesion molecule-1 (ICAM-1) is an important adhesion molecule that plays a key role in the tight adhesion between leukocytes and vascular endothelium. The object of this study was to investigate the association between the K469E polymorphism of the ICAM-1 gene and restenosis after coronary stenting in North Chinese population.
Methods The ICAM-1 K469E polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism method in 124 patients who had undergone coronary stenting and coronary angiography at least 3 months earlier. Informaiton on clinical risk factors and procedure-related data was also collected.
Results Of 124 enrolled patients in total, there were 72 cases of in-stent restenosis. The restenosis rate in this population was 58.1%. The frequencies of the three possible genotypes of the ICAM-1 K469E polymorphism were: KK genotype 50.8%, EE genotype 41.9% and EK genotype 41.9%. Among restenosis patients, the frequency of the KK genotype was 58.3% and the frequency of E allele carriers was 41.7%. Among non-restenosis patients, the frequency was significantly different (P=0.049). Using multivariate logistic regression, the difference between the two groups was more apparent. The odds ratio of KK homozygotes vs. E allele carriers was 2.6, with 95% confidence interval 1.2-5.8 (P=0.018). After grading of risk factors, we found that the KK genotype was a stronger predictor of in-stent restenosis in obesity or hyperlipemia patients, with an odds ratio of 9.3 and 3.7, respectively (P < 0.05).
Conclusion In our study population, KK homozygotes of the ICAM-1 codon 469 mutation had a higher risk of restenosis after coronary stenting, especially in the case of obese or hyperlipemia patients.
|作者单位||1.Anhui Province Biomed Inst, Hefei 230032, Peoples R China|
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
3.Univ Sci & Technol China, Dept Biosci, Hefei 230026, Peoples R China
|Liu, ZP,Huo, Y,Li, JP,et al. Polymorphism K469E of intercellular adhesion molecule-1 gene and restenosis after coronary stenting in Chinese patients[J]. CHINESE MEDICAL JOURNAL,2004,117(2):172-175.|
|APA||Liu, ZP.,Huo, Y.,Li, JP.,Zhang, Y.,Xue, L.,...&Gao, W.(2004).Polymorphism K469E of intercellular adhesion molecule-1 gene and restenosis after coronary stenting in Chinese patients.CHINESE MEDICAL JOURNAL,117(2),172-175.|
|MLA||Liu, ZP,et al."Polymorphism K469E of intercellular adhesion molecule-1 gene and restenosis after coronary stenting in Chinese patients".CHINESE MEDICAL JOURNAL 117.2(2004):172-175.|