IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases
Zhang, Yan1; Qin, Xian-hui2; Li, Jian-ping1; Cui, Yi-min3; Liu, Ze-yuan4; Zhao, Zhi-gang5; Ge, Jun-bo6; Guan, De-ming7; Hu, Jian8; Wang, Yan-ni9; Zhang, Fu-min10; Xu, Xin11; Xu, Xi-ping11; Huo, Yong1
关键词Alanine Aminotransferase (Alt) Body Mass Index (Bmi) Waist Circumference (Wc) Folate
刊名JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
2013-08-01
DOI10.1631/jzus.B1200330
14期:8页:743-748
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]NONALCOHOLIC FATTY LIVER ; ALANINE AMINOTRANSFERASE ACTIVITY ; CARDIOVASCULAR-DISEASE ; METABOLIC SYNDROME ; ENZYME ACTIVITY ; ADIPOSE-TISSUE ; UNITED-STATES ; FOLIC-ACID ; HOMOCYSTEINE ; RISK
英文摘要

High body mass index (BMI) is considered as the most important risk factor for elevated serum alanine aminotransferase (ALT) concentration. This study examined an array of factors, including waist circumference (WC) and folate deficiency, which may mediate the association of BMI with serum ALT concentration in Chinese hypertensive adults without known hepatic diseases.

A multicenter, cross-sectional study was carried out. A total of 378 patients with mild or moderate hypertension and without known hepatic diseases were recruited from five hospitals in Harbin, Shanghai, Beijing, Xi′an, and Nanjing.

Of the 360 hypertensive patients with complete data in our final analysis, 13.6% had high ALT concentrations (> 40 IU/L). Factors including BMI, WC, triglyceride level, and folate concentration were associated with ALT concentration in univariate analysis. Consistently higher prevalence rates of elevated ALT were observed in subjects with lower folate concentrations (a parts per thousand yen12 vs. < 12 nmol/L, 9.9% vs. 17.8%, P=0.03), with higher BMI (a parts per thousand yen28 vs. < 28 kg/m(2), 21.5% vs. 11.4%, P=0.02) or higher WC (a parts per thousand yen90 vs. < 90 cm, 18.5% vs. 10.0%, P=0.02). However, in multivariate analysis, the association between BMI and ALT concentration disappeared (P=0.802 in males and 0.369 in females), while WC in females (P < 0.001) and folate concentration (P=0.036 in males and 0.044 in females) remained as significant predictors for ALT concentration.

This multicenter study demonstrated that WC and low folate concentration were important factors underlying the association between BMI and ALT concentrations in Chinese hypertensive adults without known hepatic diseases.

语种英语
WOS记录号WOS:000322717000012
项目编号2012zx09101-105 ; 2012CB517703
资助机构Ministry of Science and Technology of China ; National Basic Research Program (973) of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57259
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China
2.Southern Med Univ, Div Nephrol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
3.Peking Univ, Dept Clin Pharmacol, Hosp 1, Beijing 100034, Peoples R China
4.Acad Mil Med Sci, Dept Pharm, Affiliated Hosp 1, Beijing 100071, Peoples R China
5.Capital Med Univ, Dept Pharm, Beijing Tiantan Hosp, Beijing 100050, Peoples R China
6.Fudan Univ, Dept Cardiol, Zhongshan Hosp, Shanghai 200032, Peoples R China
7.Harbin Med Univ, Dept Cardiol, Clin Med Coll 1, Harbin 150001, Peoples R China
8.China Med Univ, Dept Cardiol, Affiliated Hosp 1, Shenyang 110001, Peoples R China
9.Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 1, Sch Med, Xian 710061, Peoples R China
10.Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
11.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou 510515, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yan,Qin, Xian-hui,Li, Jian-ping,et al. Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2013,14(8):743-748.
APA Zhang, Yan.,Qin, Xian-hui.,Li, Jian-ping.,Cui, Yi-min.,Liu, Ze-yuan.,...&Huo, Yong.(2013).Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,14(8),743-748.
MLA Zhang, Yan,et al."Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 14.8(2013):743-748.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Yan]的文章
[Qin, Xian-hui]的文章
[Li, Jian-ping]的文章
百度学术
百度学术中相似的文章
[Zhang, Yan]的文章
[Qin, Xian-hui]的文章
[Li, Jian-ping]的文章
必应学术
必应学术中相似的文章
[Zhang, Yan]的文章
[Qin, Xian-hui]的文章
[Li, Jian-ping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。