|Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases|
|Zhang, Yan1; Qin, Xian-hui2; Li, Jian-ping1; Cui, Yi-min3; Liu, Ze-yuan4; Zhao, Zhi-gang5; Ge, Jun-bo6; Guan, De-ming7; Hu, Jian8; Wang, Yan-ni9; Zhang, Fu-min10; Xu, Xin11; Xu, Xi-ping11; Huo, Yong1|
|关键词||Alanine Aminotransferase (Alt) Body Mass Index (Bmi) Waist Circumference (Wc) Folate|
|刊名||JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B|
|WOS标题词||Science & Technology|
|类目[WOS]||Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental|
|研究领域[WOS]||Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine|
|关键词[WOS]||NONALCOHOLIC FATTY LIVER ; ALANINE AMINOTRANSFERASE ACTIVITY ; CARDIOVASCULAR-DISEASE ; METABOLIC SYNDROME ; ENZYME ACTIVITY ; ADIPOSE-TISSUE ; UNITED-STATES ; FOLIC-ACID ; HOMOCYSTEINE ; RISK|
High body mass index (BMI) is considered as the most important risk factor for elevated serum alanine aminotransferase (ALT) concentration. This study examined an array of factors, including waist circumference (WC) and folate deficiency, which may mediate the association of BMI with serum ALT concentration in Chinese hypertensive adults without known hepatic diseases.
A multicenter, cross-sectional study was carried out. A total of 378 patients with mild or moderate hypertension and without known hepatic diseases were recruited from five hospitals in Harbin, Shanghai, Beijing, Xi′an, and Nanjing.
Of the 360 hypertensive patients with complete data in our final analysis, 13.6% had high ALT concentrations (> 40 IU/L). Factors including BMI, WC, triglyceride level, and folate concentration were associated with ALT concentration in univariate analysis. Consistently higher prevalence rates of elevated ALT were observed in subjects with lower folate concentrations (a parts per thousand yen12 vs. < 12 nmol/L, 9.9% vs. 17.8%, P=0.03), with higher BMI (a parts per thousand yen28 vs. < 28 kg/m(2), 21.5% vs. 11.4%, P=0.02) or higher WC (a parts per thousand yen90 vs. < 90 cm, 18.5% vs. 10.0%, P=0.02). However, in multivariate analysis, the association between BMI and ALT concentration disappeared (P=0.802 in males and 0.369 in females), while WC in females (P < 0.001) and folate concentration (P=0.036 in males and 0.044 in females) remained as significant predictors for ALT concentration.
This multicenter study demonstrated that WC and low folate concentration were important factors underlying the association between BMI and ALT concentrations in Chinese hypertensive adults without known hepatic diseases.
|项目编号||2012zx09101-105 ; 2012CB517703|
|资助机构||Ministry of Science and Technology of China ; National Basic Research Program (973) of China|
|作者单位||1.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China|
2.Southern Med Univ, Div Nephrol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
3.Peking Univ, Dept Clin Pharmacol, Hosp 1, Beijing 100034, Peoples R China
4.Acad Mil Med Sci, Dept Pharm, Affiliated Hosp 1, Beijing 100071, Peoples R China
5.Capital Med Univ, Dept Pharm, Beijing Tiantan Hosp, Beijing 100050, Peoples R China
6.Fudan Univ, Dept Cardiol, Zhongshan Hosp, Shanghai 200032, Peoples R China
7.Harbin Med Univ, Dept Cardiol, Clin Med Coll 1, Harbin 150001, Peoples R China
8.China Med Univ, Dept Cardiol, Affiliated Hosp 1, Shenyang 110001, Peoples R China
9.Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 1, Sch Med, Xian 710061, Peoples R China
10.Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
11.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou 510515, Guangdong, Peoples R China
|Zhang, Yan,Qin, Xian-hui,Li, Jian-ping,et al. Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2013,14(8):743-748.|
|APA||Zhang, Yan.,Qin, Xian-hui.,Li, Jian-ping.,Cui, Yi-min.,Liu, Ze-yuan.,...&Huo, Yong.(2013).Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,14(8),743-748.|
|MLA||Zhang, Yan,et al."Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 14.8(2013):743-748.|