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学科主题临床医学
Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia
Sun, W; Wang, G; Zhang, ZM; Zeng, XK; Wang, X
关键词Homocysteine Monocytes Rantes Folic Acid Atherosclerosis Humans
刊名ACTA PHARMACOLOGICA SINICA
2005-11-01
DOI10.1111/j.1745-7254.2005.00178.x
26期:11页:1317-1321
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CHEMOATTRACTANT PROTEIN-1 ; VASCULAR-DISEASE ; HOMOCYSTEINE ; ATHEROSCLEROSIS ; SECRETION ; CELLS ; INTERLEUKIN-8 ; EXPRESSION ; RISK
英文摘要

Aim: To investigate the changes in plasma level of the chemokine RANTES (regulated upon activation, normal T cells expressed and secreted) and the responsiveness of lipopolysaccharide (LPS)-induced RANTES secretion from monocytes in patients with hyperhomocysteinemia (HHcy). Methods: The plasma levels of homocysteine (Hcy), folate, and RANTES were measured in 38 control patients with normal Hcy levels and 40 patients with HHcy and the mRNA synthesis of RANTES in isolated human monocytes was determined by RNase protection assays. Results: The plasma level of RANTES was elevated in HHcy patients compared with controls (median 5.3 vs 3.5 ng/mL, P < 0.01). LPS-induced RANTES production from monocytes of HHcy patients was also increased significantly. In addition, Hcy directly increased the mRNA level of RANTES in isolated normal human monocytes in a time- and dose-dependent manner. Conclusion: Upregulated RANTES from monocytes in HHcy patients may be involved in the atherogenesis of HHcy-induced atherosclerosis.

语种英语
WOS记录号WOS:000233209800007
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57263
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ Third Hosp, Inst Vasc Med, Beijing 100083, Peoples R China
2.Peking Univ Third Hosp, Dept Gerontol, Beijing 100083, Peoples R China
3.Peking Univ, Basic Med Coll, Dept Physiol & Pathophysiol, Minist Educ,Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
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Sun, W,Wang, G,Zhang, ZM,et al. Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia[J]. ACTA PHARMACOLOGICA SINICA,2005,26(11):1317-1321.
APA Sun, W,Wang, G,Zhang, ZM,Zeng, XK,&Wang, X.(2005).Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia.ACTA PHARMACOLOGICA SINICA,26(11),1317-1321.
MLA Sun, W,et al."Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia".ACTA PHARMACOLOGICA SINICA 26.11(2005):1317-1321.
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