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学科主题: 临床医学
题名:
Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia
作者: Sun, W; Wang, G; Zhang, ZM; Zeng, XK; Wang, X
关键词: homocysteine ; monocytes ; RANTES ; folic acid ; atherosclerosis ; humans
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2005-11-01
DOI: 10.1111/j.1745-7254.2005.00178.x
卷: 26, 期:11, 页:1317-1321
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CHEMOATTRACTANT PROTEIN-1 ; VASCULAR-DISEASE ; HOMOCYSTEINE ; ATHEROSCLEROSIS ; SECRETION ; CELLS ; INTERLEUKIN-8 ; EXPRESSION ; RISK
英文摘要:

Aim: To investigate the changes in plasma level of the chemokine RANTES (regulated upon activation, normal T cells expressed and secreted) and the responsiveness of lipopolysaccharide (LPS)-induced RANTES secretion from monocytes in patients with hyperhomocysteinemia (HHcy). Methods: The plasma levels of homocysteine (Hcy), folate, and RANTES were measured in 38 control patients with normal Hcy levels and 40 patients with HHcy and the mRNA synthesis of RANTES in isolated human monocytes was determined by RNase protection assays. Results: The plasma level of RANTES was elevated in HHcy patients compared with controls (median 5.3 vs 3.5 ng/mL, P < 0.01). LPS-induced RANTES production from monocytes of HHcy patients was also increased significantly. In addition, Hcy directly increased the mRNA level of RANTES in isolated normal human monocytes in a time- and dose-dependent manner. Conclusion: Upregulated RANTES from monocytes in HHcy patients may be involved in the atherogenesis of HHcy-induced atherosclerosis.

语种: 英语
WOS记录号: WOS:000233209800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57263
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Inst Vasc Med, Beijing 100083, Peoples R China
2.Peking Univ Third Hosp, Dept Gerontol, Beijing 100083, Peoples R China
3.Peking Univ, Basic Med Coll, Dept Physiol & Pathophysiol, Minist Educ,Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China

Recommended Citation:
Sun, W,Wang, G,Zhang, ZM,et al. Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia[J]. ACTA PHARMACOLOGICA SINICA,2005,26(11):1317-1321.
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