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学科主题: 临床医学
题名:
In Vitro Susceptibilities of Yeast Species to Fluconazole and Voriconazole as Determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study
作者: Wang, He1; Xiao, Meng1,2; Chen, Sharon C. -A.3; Kong, Fanrong3; Sun, Zi-Yong4; Liao, Kang5; Lu, Juan6; Shao, Hai-Feng7; Yan, Yan8; Fan, Hong9; Hu, Zhi-Dong10; Chu, Yun-Zhuo11; Hu, Tie-Shi12; Ni, Yu-Xing13; Zou, Gui-Ling14; Xu, Ying-Chun1
刊名: JOURNAL OF CLINICAL MICROBIOLOGY
发表日期: 2012-12-01
DOI: 10.1128/JCM.01130-12
卷: 50, 期:12, 页:3952-3959
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: GLOBAL ANTIFUNGAL SURVEILLANCE ; STANDARDIZED DISK DIFFUSION ; BLOOD-STREAM INFECTIONS ; CANDIDA-PARAPSILOSIS ; INTERPRETIVE BREAKPOINTS ; CRYPTOCOCCUS-NEOFORMANS ; CLINICAL BREAKPOINTS ; ACTIVE SURVEILLANCE ; 10.5-YEAR ANALYSIS ; EPIDEMIOLOGY
英文摘要:

We conducted active, laboratory-based surveillance for isolates from patients with invasive infections across China from August 2009 to July 2010. DNA sequencing methods were used to define species, and susceptibility to fluconazole and voriconazole was determined by the Clinical and Laboratory Standards Institute M44-A2 disk diffusion method but using up-to-date clinical breakpoints or epidemiological cutoff values. Candida spp. made up 90.5% of the 814 yeast strains isolated, followed by Cryptococcus neoformans (7.7%) and other non-Candida yeast strains (1.7%). Bloodstream isolates made up 42.9% of the strains, isolates from ascitic fluid made up 22.1%, but pus/tissue specimens yielded yeast strains in <5% of the cases. Among the Candida isolates, Candida albicans was the most common species from specimens other than blood (50.1%) but made up only 23% of the bloodstream isolates (P<0.001). C. parapsilosis complex species were the most common Candida isolates from blood (33.2%). Uncommon bloodstream yeast strains included Trichosporon spp., C. pelliculosa, and the novel species C. quercitrusa, reported for the first time as a cause of candidemia. Most (>94%) of the isolates of C. albicans, C. tropicalis, and the C. parapsilosis complex were susceptible to fluconazole and voriconazole, as were all of the Trichosporon strains; however, 12.2% of the C. glabrata sensu stricto isolates were fluconazole resistant and 17.8% had non-wild-type susceptibility to voriconazole. Seven C. tropicalis strains were cross-resistant to fluconazole and voriconazole; six were from patients in the same institution. Resistance to fluconazole and voriconazole was seen in 31.9% and 13.3% of the uncommon Candida and non-Candida yeast strains, respectively. Causative species and azole susceptibility varied with the geographic region. This study provided clinically useful data on yeast strains and their antifungal susceptibilities in China.

语种: 英语
项目资助者: Investigator-Initiated Research grant from Pfizer, China
WOS记录号: WOS:000311211800022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57267
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Nanjing Gen Hosp, Inst Clin Lab Med PLA, Nanjing, Peoples R China
2.Peoples Hosp Liaoning Prov, Dept Clin Lab, Shenyang, Peoples R China
3.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China
5.Westmead Hosp, Ctr Infect Dis & Microbiol Lab Serv, Westmead, NSW 2145, Australia
6.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Clin Lab, Wuhan 430074, Peoples R China
7.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, Guangzhou 510275, Guangdong, Peoples R China
8.Harbin Med Univ, Affiliated Hosp 1, Dept Clin Lab, Harbin, Peoples R China
9.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
10.Sichuan Univ, W China Hosp, Lab Clin Microbiol, Chengdu 610064, Peoples R China
11.Tianjin Med Univ, Gen Hosp, Dept Clin Lab, Tianjin, Peoples R China
12.China Med Univ, Hosp 1, Dept Clin Lab, Shenyang, Peoples R China
13.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Clin Microbiol & Infect Control, Shanghai, Peoples R China
14.Harbin Med Univ, Affiliated Hosp 4, Dept Clin Lab, Harbin, Peoples R China

Recommended Citation:
Wang, He,Xiao, Meng,Chen, Sharon C. -A.,et al. In Vitro Susceptibilities of Yeast Species to Fluconazole and Voriconazole as Determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2012,50(12):3952-3959.
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