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学科主题: 临床医学
题名:
Detection of human papillomavirus-16 in ovarian malignancy
作者: Wu, QJ; Guo, M; Lu, ZM; Li, T; Qiao, HZ; Ke, Y
关键词: human papillomavirus-16 ; p53 tumour suppressor gene ; ovarian malignancy
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2003-08-18
DOI: 10.1038/sj.bjc.6601172
卷: 89, 期:4, 页:672-675
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SQUAMOUS INTRAEPITHELIAL NEOPLASIA ; UPPER GENITAL-TRACT ; CERVICAL-CANCER ; WORLDWIDE PERSPECTIVE ; CELL CARCINOMA ; P53 MUTATION ; TYPE-16 ; INFECTION ; ASSOCIATION ; WOMEN
英文摘要:

Human papillomavirus is the causal factor for cervical cancer. However, the role of HPV infection in ovarian cancer is unclear. This study aimed to determine the presence of human papillomavirus-16 (HPV-16) in ovarian cancer tissues. Archived human ovarian cancer tissues (N = 54 cases, 50 are epithelial cancer, four are nonepithelial cancer) embedded in paraffin blocks were used. Controls are 30 nonmalignant ovarian tissue blocks. In situ hybridisation ( ISH) and immunohistochemistry (IHC) were used to detect the presence of HPV-16 and p53 expression. In all, 52 or 36% of the epithelial ovarian tumours detected by ISH or IHC, respectively, were HPV-16 E6 positive. In contrast, only 6.7% of normal ovarian tissues were HPV-16 positive proved by ISH. Human papillomavirus-16 infection was significantly higher in cancer tissues compared to controls with an odds ratio of 16.7 (95% confidence interval [CI] = 3.2-71.4, P < 0.01). No significant correlation between HPV-16 infection and histological types of cancer was found (P > 0.05). p53 gene expression was detected in 42% epithelial ovarian cancers. No correlation between p53 expression and HPV-16 infection was found. The results showed the presence of HPV-16 E6 in ovarian carcinoma, suggesting that HPV infection might play a role in ovarian carcinogenesis.

语种: 英语
WOS记录号: WOS:000184799100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57271
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Genet Lab, Beijing 100034, Peoples R China
2.Inner Mongolia Med Coll, Hohhot 010000, Hohehot Municip, Peoples R China

Recommended Citation:
Wu, QJ,Guo, M,Lu, ZM,et al. Detection of human papillomavirus-16 in ovarian malignancy[J]. BRITISH JOURNAL OF CANCER,2003,89(4):672-675.
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