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学科主题临床医学
Detection of human papillomavirus-16 in ovarian malignancy
Wu, QJ; Guo, M; Lu, ZM; Li, T; Qiao, HZ; Ke, Y
关键词Human Papillomavirus-16 P53 Tumour Suppressor Gene Ovarian Malignancy
刊名BRITISH JOURNAL OF CANCER
2003-08-18
DOI10.1038/sj.bjc.6601172
89期:4页:672-675
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SQUAMOUS INTRAEPITHELIAL NEOPLASIA ; UPPER GENITAL-TRACT ; CERVICAL-CANCER ; WORLDWIDE PERSPECTIVE ; CELL CARCINOMA ; P53 MUTATION ; TYPE-16 ; INFECTION ; ASSOCIATION ; WOMEN
英文摘要

Human papillomavirus is the causal factor for cervical cancer. However, the role of HPV infection in ovarian cancer is unclear. This study aimed to determine the presence of human papillomavirus-16 (HPV-16) in ovarian cancer tissues. Archived human ovarian cancer tissues (N = 54 cases, 50 are epithelial cancer, four are nonepithelial cancer) embedded in paraffin blocks were used. Controls are 30 nonmalignant ovarian tissue blocks. In situ hybridisation ( ISH) and immunohistochemistry (IHC) were used to detect the presence of HPV-16 and p53 expression. In all, 52 or 36% of the epithelial ovarian tumours detected by ISH or IHC, respectively, were HPV-16 E6 positive. In contrast, only 6.7% of normal ovarian tissues were HPV-16 positive proved by ISH. Human papillomavirus-16 infection was significantly higher in cancer tissues compared to controls with an odds ratio of 16.7 (95% confidence interval [CI] = 3.2-71.4, P < 0.01). No significant correlation between HPV-16 infection and histological types of cancer was found (P > 0.05). p53 gene expression was detected in 42% epithelial ovarian cancers. No correlation between p53 expression and HPV-16 infection was found. The results showed the presence of HPV-16 E6 in ovarian carcinoma, suggesting that HPV infection might play a role in ovarian carcinogenesis.

语种英语
WOS记录号WOS:000184799100013
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被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57271
专题北京大学临床肿瘤学院_遗传学研究室
作者单位1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Genet Lab, Beijing 100034, Peoples R China
2.Inner Mongolia Med Coll, Hohhot 010000, Hohehot Municip, Peoples R China
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GB/T 7714
Wu, QJ,Guo, M,Lu, ZM,et al. Detection of human papillomavirus-16 in ovarian malignancy[J]. BRITISH JOURNAL OF CANCER,2003,89(4):672-675.
APA Wu, QJ,Guo, M,Lu, ZM,Li, T,Qiao, HZ,&Ke, Y.(2003).Detection of human papillomavirus-16 in ovarian malignancy.BRITISH JOURNAL OF CANCER,89(4),672-675.
MLA Wu, QJ,et al."Detection of human papillomavirus-16 in ovarian malignancy".BRITISH JOURNAL OF CANCER 89.4(2003):672-675.
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