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学科主题: 基础医学
题名:
QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats
作者: Tang, Dong-Xin1,2,3; Zhao, Hai-Ping2; Pan, Chun-Shui2; Liu, Yu-Ying2; Wei, Xiao-Hong2; Yang, Xiao-Yuan2,4; Chen, Yuan-Yuan2,4; Fan, Jing-Yu2; Wang, Chuan-She2,4; Han, Jing-Yan2,4; Li, Ping-Ping1
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/480597
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: HEART-FAILURE ; ACTIVATION
英文摘要:

QiShenYiQi Pills (QSYQ) is a compound Chinese medicine used for treatment of cardiovascular diseases.. e present study investigated the effects of QSYQ on the Doxorubicin- (DOX-) induced disorders in rat cardiac structure and function and the possible mechanism underlying. A total of 24 male Sprague-Dawley rats were administrated by intraperitoneal injections with DOX at a dose of 2.5 mg/kg, once every day for a total of 6 times. After the 6th injection, the rats were evaluated by echocardiographic analysis, and the animals with injured heart (n = 14) were divided into 2 groups and further treated with (n = 7) or without (n = 7) QSYQ by gavage at a dose of 0.2 g/day, once a day, over the next 2 weeks. Two weeks after QSYQ treatment, the following variables were assessed: myocardial blood flow (MBF) by Laser-Doppler Perfusion Imager, the ratio of heart weight to body weight (HW/BW), myocardial histology, myocardial content of ATP, AMP, free fatty acids (FFAs) and AMP/ATP by ELISA, and expression of PPAR alpha, PGC-1 alpha, and ATP 5D by Western blot. Statistical analysis was performed using one-way ANOVA followed by Turkey test for multiple comparisons. DOX challenge significantly increased left ventricular internal diameter and HW/BW and decreased the thickness of the left ventricular posterior wall, the left ventricle ejection fraction, and the left ventricle fractional shortening. DOX also increased AMP, FFA, and AMP/ATP, decreased ATP, and downregulated the protein content of ATP 5D, PPAR alpha, and PGC-1 alpha. All these DOX-induced cardiac insults were attenuated significantly by QSYQ treatment. These results show the potential of QSYQ to ameliorate DOX-induced disorders in cardiac structure and function; this effect may be related to the increase in myocardial ATP content via the upregulation of ATP 5D, PPAR alpha, and PGC-1 alpha and the oxidation of FFA.

语种: 英语
所属项目编号: 2004-IV15 ; 2011-LKZ7041 ; 2008ZX09401 ; 20050230
项目资助者: Key Program Foundation of Beijing Administration of Traditional Chinese Medicines ; Joint Fund of Guizhou Provincial Department of Science and Technology-Guiyang College of Traditional Chinese Medicine ; Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China ; Tianjin Tasly Group, Tianjin, China
WOS记录号: WOS:000315904500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57273
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Integrated Tradit Chinese & Western Med, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.Guiyang Coll TCM, Affiliated Hosp 1, Dept Oncol, Guiyang 550002, Guizhou, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China

Recommended Citation:
Tang, Dong-Xin,Zhao, Hai-Ping,Pan, Chun-Shui,et al. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
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