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学科主题: 基础医学
题名:
CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest
作者: Huang, Jing1,2; Zhang, Li1,2; Liu, Wei1,2; Liao, Qinyuan1,2; Shi, Taiping1,2; Xiao, Lin1,2; Hu, Fanlei1,2; Qiu, Xiaoyan1,2
关键词: CCDC134 ; hADA2a ; PCAF ; p53 ; Acetylation
刊名: HISTOCHEMISTRY AND CELL BIOLOGY
发表日期: 2012-07-01
DOI: 10.1007/s00418-012-0932-5
卷: 138, 期:1, 页:41-55
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Microscopy
研究领域[WOS]: Cell Biology ; Microscopy
关键词[WOS]: TATA-BINDING PROTEIN ; HISTONE ACETYLATION ; P53 ACETYLATION ; HUMAN ADA3 ; COMPLEX ; ACTIVATION ; PCAF ; GCN5 ; TRANSCRIPTION ; COACTIVATORS
英文摘要:

Human transcriptional adaptor hADA2a is an important component of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Here, we report that coiled-coil domain containing 134 (CCDC134), a novel nuclear protein, binds to hADA2a and enhances the stability of the hADA2a protein in unstressed conditions. Furthermore, CCDC134 was found to participate in the p300/CBP-associated factor (PCAF) complex via hADA2a and affect the histone acetyltransferase activity of the complex. We also found that CCDC134 increased the PCAF-dependent K320 acetylation of p53 and p53 protein stability in the presence of hADA2a overexpression. Moreover, we demonstrated the biological significance of the interaction between CCDC134 and hADA2a. CCDC134 showed obvious nuclear accumulation after ultraviolet (UV) irradiation, and the knockdown of endogenous CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest. Together, our findings indicate that CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair.

语种: 英语
所属项目编号: 30901303 ; 20090001120033 ; 2012ZX09103301-032
项目资助者: National Natural Sciences Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; National Science and Technology Major Projects of New Drugs
WOS记录号: WOS:000305222300004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57274
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Immunol, Dept Immunol,Sch Basic Med Sci,Minist Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Jing,Zhang, Li,Liu, Wei,et al. CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest[J]. HISTOCHEMISTRY AND CELL BIOLOGY,2012,138(1):41-55.
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