学科主题基础医学
CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest
Huang, Jing1,2; Zhang, Li1,2; Liu, Wei1,2; Liao, Qinyuan1,2; Shi, Taiping1,2; Xiao, Lin1,2; Hu, Fanlei1,2; Qiu, Xiaoyan1,2
关键词CCDC134 hADA2a PCAF p53 Acetylation
刊名HISTOCHEMISTRY AND CELL BIOLOGY
2012-07-01
DOI10.1007/s00418-012-0932-5
138期:1页:41-55
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Microscopy
资助者National Natural Sciences Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; National Science and Technology Major Projects of New Drugs ; National Natural Sciences Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; National Science and Technology Major Projects of New Drugs
研究领域[WOS]Cell Biology ; Microscopy
关键词[WOS]TATA-BINDING PROTEIN ; HISTONE ACETYLATION ; P53 ACETYLATION ; HUMAN ADA3 ; COMPLEX ; ACTIVATION ; PCAF ; GCN5 ; TRANSCRIPTION ; COACTIVATORS
英文摘要

Human transcriptional adaptor hADA2a is an important component of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Here, we report that coiled-coil domain containing 134 (CCDC134), a novel nuclear protein, binds to hADA2a and enhances the stability of the hADA2a protein in unstressed conditions. Furthermore, CCDC134 was found to participate in the p300/CBP-associated factor (PCAF) complex via hADA2a and affect the histone acetyltransferase activity of the complex. We also found that CCDC134 increased the PCAF-dependent K320 acetylation of p53 and p53 protein stability in the presence of hADA2a overexpression. Moreover, we demonstrated the biological significance of the interaction between CCDC134 and hADA2a. CCDC134 showed obvious nuclear accumulation after ultraviolet (UV) irradiation, and the knockdown of endogenous CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest. Together, our findings indicate that CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair.

语种英语
所属项目编号30901303 ; 20090001120033 ; 2012ZX09103301-032
资助者National Natural Sciences Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; National Science and Technology Major Projects of New Drugs ; National Natural Sciences Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; National Science and Technology Major Projects of New Drugs
WOS记录号WOS:000305222300004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57274
专题基础医学院_北京大学人类疾病基因研究中心
作者单位1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Immunol, Dept Immunol,Sch Basic Med Sci,Minist Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Huang, Jing,Zhang, Li,Liu, Wei,et al. CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest[J]. HISTOCHEMISTRY AND CELL BIOLOGY,2012,138(1):41-55.
APA Huang, Jing.,Zhang, Li.,Liu, Wei.,Liao, Qinyuan.,Shi, Taiping.,...&Qiu, Xiaoyan.(2012).CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.HISTOCHEMISTRY AND CELL BIOLOGY,138(1),41-55.
MLA Huang, Jing,et al."CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest".HISTOCHEMISTRY AND CELL BIOLOGY 138.1(2012):41-55.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
CCDC134 interacts wi(897KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, Jing]的文章
[Zhang, Li]的文章
[Liu, Wei]的文章
百度学术
百度学术中相似的文章
[Huang, Jing]的文章
[Zhang, Li]的文章
[Liu, Wei]的文章
必应学术
必应学术中相似的文章
[Huang, Jing]的文章
[Zhang, Li]的文章
[Liu, Wei]的文章
相关权益政策
暂无数据
收藏/分享
文件名: CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。