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Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study
Gao, Weijiao1; Weng, Jinlong2; Gao, Yunong1; Chen, Xiaochi3
关键词Bacterial Vaginosis (Bv) Human Papillomavirus (Hpv) Polymerase Chain Reaction-denaturing Gradient Gel Electrophoresis (Dgge) Vaginal Microbiota
刊名BMC INFECTIOUS DISEASES
2013-06-10
DOI10.1186/1471-2334-13-271
13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]GRADIENT GEL-ELECTROPHORESIS ; CULTIVATION-INDEPENDENT METHODS ; 16S RIBOSOMAL-RNA ; BACTERIAL VAGINOSIS ; GARDNERELLA-VAGINALIS ; CERVICAL NEOPLASIA ; NATURAL-HISTORY ; HPV INFECTION ; PCR ; COMMUNITIES
英文摘要

Background: The female genital tract is an important bacterial habitat of the human body, and vaginal microbiota plays a crucial role in vaginal health. The alteration of vaginal microbiota affects millions of women annually, and is associated with numerous adverse health outcomes, including human papillomavirus (HPV) infection. However, previous studies have primarily focused on the association between bacterial vaginosis and HPV infection. Little is known about the composition of vaginal microbial communities involved in HPV acquisition. The present study was performed to investigate whether HPV infection was associated with the diversity and composition of vaginal microbiota.

Methods: A total of 70 healthy women (32 HPV-negative and 38 HPV-positive) with normal cervical cytology were enrolled in this study. Culture-independent polymerase chain reaction-denaturing gradient gel electrophoresis was used to measure the diversity and composition of vaginal microbiota of all subjects.

Results: We found significantly greater biological diversity in the vaginal microbiota of HPV-positive women (p < 0.001). Lactobacillus, including L. gallinarum, L. iners and L. gasseri, was the predominant genus and was detected in all women. No significant difference between HPV-positive and HPV-negative women was found for the frequency of detection of L. gallinarum (p = 0.775) or L. iners (p = 0.717), but L. gasseri was found at a significantly higher frequency in HPV-positive women (p = 0.005). Gardnerella vaginalis was also found at a significantly higher frequency in HPV-positive women (p = 0.031). Dendrograms revealed that vaginal microbiota from the two groups had different profiles.

Conclusions: Our study is the first systematic evaluation of an association between vaginal microbiota and HPV infection, and we have demonstrated that compared with HPV-negative women, the bacterial diversity of HPV-positive women is more complex and the composition of vaginal microbiota is different.

语种英语
WOS记录号WOS:000320436200001
资助机构Peking University Cancer Hospital, Beijing Cancer Hospital and Institute
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57276
专题北京大学口腔医学院_口腔生物研究室
北京大学口腔医学院_口腔生物学教研室
北京大学口腔医学院_第一门诊部
北京大学临床肿瘤学院_妇科肿瘤科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Gynecol Oncol,Sch Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dent Clin 1, Beijing 100034, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral Biol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Gao, Weijiao,Weng, Jinlong,Gao, Yunong,et al. Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study[J]. BMC INFECTIOUS DISEASES,2013,13.
APA Gao, Weijiao,Weng, Jinlong,Gao, Yunong,&Chen, Xiaochi.(2013).Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study.BMC INFECTIOUS DISEASES,13.
MLA Gao, Weijiao,et al."Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study".BMC INFECTIOUS DISEASES 13(2013).
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