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学科主题基础医学
Thirty minute transcutaneous electric acupoint stimulation modulates resting state brain activities: A perfusion and BOLD fMRI study
Jiang, Yin2,3,4; Hao, Ying5; Zhang, Yue6; Liu, Jing7; Wang, Xiaoying5,7; Han, Jisheng2,3,4; Fang, Jing5,6; Zhang, Jue5,6; Cui, Cailian1,2,3,4
关键词Acupuncture Transcutaneous electric acupoint stimulation (TEAS) Sustained after effect Resting state Cerebral blood flow (CBF) Functional connectivity
刊名BRAIN RESEARCH
2012-05-31
DOI10.1016/j.brainres.2012.03.063
1457期:May 31页:13-25
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CEREBRAL-BLOOD-FLOW ; DEFAULT-MODE ; ACUPUNCTURE ANALGESIA ; FUNCTIONAL MRI ; CONNECTIVITY ANALYSIS ; NERVE-STIMULATION ; NEURAL RESPONSES ; PAIN ; NETWORK ; ELECTROACUPUNCTURE
英文摘要

Increasing neuroimaging studies have focused on the sustained after effects of acupuncture, especially for the changes of brain activities in rest. However, short-period stimuli have mostly been chosen in these works. The present study aimed to investigate how the resting state brain activities in healthy subjects were modulated by relatively long-period (30 min) acupuncture, a widely used modality in clinical practice. Transcutaneous electric acupoint stimulation (TEAS) or intermittent minimal TEAS (MTEAS) were given for 30 mm to 40 subjects. Functional MRI (fMRI) data were collected including the pre-stimulation resting state and the post-stimulation resting state, using dual-echo arterial spin labeling (ASL) techniques, representing both cerebral blood flow (CBF) signals and blood oxygen-dependent level (BOLD) signals simultaneously. Following 30 min TEAS, but not MTEAS, the mean global CBF decreased, and a significant decrease of regional CBF was observed in SI, insula, STG, MOG and IFG. Functional connectivity analysis showed more secure and spatially extended connectivity of both the DMN and. SMN after 30 mm TEAS. Our results implied that modulation of the regional brain activities and network connectivity induced by thirty minute TEAS may associate with the acupuncture-related therapeutic effects. Furthermore, the resting state regional CBF quantified by ASL perfusion fMRI may serve as a potential biomarker in future acupuncture studies. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000305035100002
项目编号2007CB512501 ; 2009CB522003
资助机构National Basic Research Program of China ; HSC-CoE PKU
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57280
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
北京大学第一临床医学院_医学影像科
作者单位1.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
2.Minist Publ Hlth, Beijing, Peoples R China
3.Peking Univ, Coll Engn, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
6.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China
7.Peking Univ, Hosp 1, Dept Radiol, Beijing 100191, Peoples R China
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GB/T 7714
Jiang, Yin,Hao, Ying,Zhang, Yue,et al. Thirty minute transcutaneous electric acupoint stimulation modulates resting state brain activities: A perfusion and BOLD fMRI study[J]. BRAIN RESEARCH,2012,1457(May 31):13-25.
APA Jiang, Yin.,Hao, Ying.,Zhang, Yue.,Liu, Jing.,Wang, Xiaoying.,...&Cui, Cailian.(2012).Thirty minute transcutaneous electric acupoint stimulation modulates resting state brain activities: A perfusion and BOLD fMRI study.BRAIN RESEARCH,1457(May 31),13-25.
MLA Jiang, Yin,et al."Thirty minute transcutaneous electric acupoint stimulation modulates resting state brain activities: A perfusion and BOLD fMRI study".BRAIN RESEARCH 1457.May 31(2012):13-25.
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