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学科主题: 公共卫生
题名:
Susceptibility genes for diabetic retinopathy
作者: Li, Juan; Hu, Yong-Hua
关键词: diabetic retinopathy ; susceptibility gene
刊名: INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
发表日期: 2009-03-18
卷: 2, 期:1, 页:1-6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: EPITHELIUM-DERIVED FACTOR ; ALDOSE REDUCTASE GENE ; CONVERTING-ENZYME GENE ; ENDOTHELIAL GROWTH-FACTOR ; OXIDE SYNTHASE GENE ; INSERTION DELETION POLYMORPHISM ; NITRIC-OXIDE ; MICROVASCULAR COMPLICATIONS ; END-PRODUCTS ; RAGE GENE
英文摘要:

Diabetic retinopathy (DR) is a sight-threatening chronic complication of diabetes mellitus and is the leading cause of acquired blindness in adults. Long-term exposure to the hyperglycemia of diabetes patients leads to the development of DR. Several studies have provided evidence that good diabetes control is important to prevent DR. However, emerging evidence suggests that genes are a significant contributor to an individual′s risk of retinopathy. This evidence is from evaluations of familial aggregation and different incidence of DR in racial and ethnic groups. Some groups of patients develop DR despite good control and some escape retinopathy despite poor control. This suggests that the genes are involved in the susceptibility to DR. Genes suggested as having a role include those encoding aldose reductase, nitric oxide synthase, receptor for advanced glycation end products, angiotensin converting enzyme, vascular endothelial growth factors and pigment epithelium-derived factor. An understanding of the role of susceptibility genes will ultimately allow the development of novel therapeutic strategies. This article reviews the role of genetic factors in the etiology and progression of DR.

语种: 英语
WOS记录号: WOS:000282933700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57282
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Li, Juan,Hu, Yong-Hua. Susceptibility genes for diabetic retinopathy[J]. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,2009,2(1):1-6.
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