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Susceptibility genes for diabetic retinopathy
Li, Juan; Hu, Yong-Hua
关键词Diabetic Retinopathy Susceptibility Gene
刊名INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2009-03-18
2期:1页:1-6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]EPITHELIUM-DERIVED FACTOR ; ALDOSE REDUCTASE GENE ; CONVERTING-ENZYME GENE ; ENDOTHELIAL GROWTH-FACTOR ; OXIDE SYNTHASE GENE ; INSERTION DELETION POLYMORPHISM ; NITRIC-OXIDE ; MICROVASCULAR COMPLICATIONS ; END-PRODUCTS ; RAGE GENE
英文摘要

Diabetic retinopathy (DR) is a sight-threatening chronic complication of diabetes mellitus and is the leading cause of acquired blindness in adults. Long-term exposure to the hyperglycemia of diabetes patients leads to the development of DR. Several studies have provided evidence that good diabetes control is important to prevent DR. However, emerging evidence suggests that genes are a significant contributor to an individual′s risk of retinopathy. This evidence is from evaluations of familial aggregation and different incidence of DR in racial and ethnic groups. Some groups of patients develop DR despite good control and some escape retinopathy despite poor control. This suggests that the genes are involved in the susceptibility to DR. Genes suggested as having a role include those encoding aldose reductase, nitric oxide synthase, receptor for advanced glycation end products, angiotensin converting enzyme, vascular endothelial growth factors and pigment epithelium-derived factor. An understanding of the role of susceptibility genes will ultimately allow the development of novel therapeutic strategies. This article reviews the role of genetic factors in the etiology and progression of DR.

语种英语
WOS记录号WOS:000282933700001
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57282
专题北京大学公共卫生学院
北京大学临床肿瘤学院_麻醉科
作者单位Peking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, Juan,Hu, Yong-Hua. Susceptibility genes for diabetic retinopathy[J]. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,2009,2(1):1-6.
APA Li, Juan,&Hu, Yong-Hua.(2009).Susceptibility genes for diabetic retinopathy.INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,2(1),1-6.
MLA Li, Juan,et al."Susceptibility genes for diabetic retinopathy".INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2.1(2009):1-6.
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