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学科主题: 临床医学
题名:
IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation
作者: Zhao, Xiang-Yu; Xu, Ling-Ling; Lu, Sheng-Ye; Huang, Xiao-Jun1
关键词: GVHD ; Tc1 ; Tc17 ; Th1 ; Th17
刊名: EUROPEAN JOURNAL OF IMMUNOLOGY
发表日期: 2011-02-01
DOI: 10.1002/eji.201040793
卷: 41, 期:2, 页:514-526
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: COLONY-STIMULATING FACTOR ; INTERFERON-GAMMA ; HELPER-CELLS ; IN-VIVO ; TH17 ; HYPORESPONSIVENESS ; DIFFERENTIATION ; EXPRESSION ; ABSENCE ; IL-17
英文摘要:

The aim of this study was to investigate the effects of IL-17-producing T cells, including Th17 and Tc17 cells, on acute graft-versus-host disease (aGVHD) in patients who had undergone granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (G-BM) transplantation. Allografts from forty-one patients were analysed for IL-17-producing T cells with respect to aGVHD. Furthermore, ten patients with aGVHD onset were monitored for the presence of Th17 cells in the peripheral blood by flow cytometry. Patients who received a higher dose of Th17 cells in the G-BM (>8.5 x 10(4)/kg, p = 0.005) or a higher dose of Tc17 cells in PBPC (>16.8 x 10(4)/kg, p = 0.001) exhibited a higher incidence of aGVHD. An increased Th17 population (up to 4.99% CD4(+) T lymphocytes) was observed in patients with aGVHD onset. In contrast, the percentage of Th17 population decreased drastically in aGVHD patients following treatment to achieve partial and complete remission (p = 0.013 and p = 0.008, respectively). All percentages of Th17 and Tc17 cells were significantly reduced after in vivo G-CSF application. Our results suggested that IL-17-producing T cells contributed to aGVHD. The application of G-CSF in vivo aided in reducing the occurrence of aGVHD through a decrease in IL-17 secretion by T cells.

语种: 英语
所属项目编号: 30725038 ; 30971292 ; 30800485 ; 2008B05
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Beijing Novel Program
WOS记录号: WOS:000287159600027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57286
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Haematol, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, Xiang-Yu,Xu, Ling-Ling,Lu, Sheng-Ye,et al. IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2011,41(2):514-526.
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