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学科主题临床医学
IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation
Zhao, Xiang-Yu; Xu, Ling-Ling; Lu, Sheng-Ye; Huang, Xiao-Jun1
关键词Gvhd Tc1 Tc17 Th1 Th17
刊名EUROPEAN JOURNAL OF IMMUNOLOGY
2011-02-01
DOI10.1002/eji.201040793
41期:2页:514-526
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]COLONY-STIMULATING FACTOR ; INTERFERON-GAMMA ; HELPER-CELLS ; IN-VIVO ; TH17 ; HYPORESPONSIVENESS ; DIFFERENTIATION ; EXPRESSION ; ABSENCE ; IL-17
英文摘要

The aim of this study was to investigate the effects of IL-17-producing T cells, including Th17 and Tc17 cells, on acute graft-versus-host disease (aGVHD) in patients who had undergone granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (G-BM) transplantation. Allografts from forty-one patients were analysed for IL-17-producing T cells with respect to aGVHD. Furthermore, ten patients with aGVHD onset were monitored for the presence of Th17 cells in the peripheral blood by flow cytometry. Patients who received a higher dose of Th17 cells in the G-BM (>8.5 x 10(4)/kg, p = 0.005) or a higher dose of Tc17 cells in PBPC (>16.8 x 10(4)/kg, p = 0.001) exhibited a higher incidence of aGVHD. An increased Th17 population (up to 4.99% CD4(+) T lymphocytes) was observed in patients with aGVHD onset. In contrast, the percentage of Th17 population decreased drastically in aGVHD patients following treatment to achieve partial and complete remission (p = 0.013 and p = 0.008, respectively). All percentages of Th17 and Tc17 cells were significantly reduced after in vivo G-CSF application. Our results suggested that IL-17-producing T cells contributed to aGVHD. The application of G-CSF in vivo aided in reducing the occurrence of aGVHD through a decrease in IL-17 secretion by T cells.

语种英语
WOS记录号WOS:000287159600027
项目编号30725038 ; 30971292 ; 30800485 ; 2008B05
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Beijing Novel Program
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57286
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Haematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xiang-Yu,Xu, Ling-Ling,Lu, Sheng-Ye,et al. IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2011,41(2):514-526.
APA Zhao, Xiang-Yu,Xu, Ling-Ling,Lu, Sheng-Ye,&Huang, Xiao-Jun.(2011).IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation.EUROPEAN JOURNAL OF IMMUNOLOGY,41(2),514-526.
MLA Zhao, Xiang-Yu,et al."IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation".EUROPEAN JOURNAL OF IMMUNOLOGY 41.2(2011):514-526.
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