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学科主题临床医学
Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma
Zhang, Jing1; Wang, Xinmao2; Chen, Yahong1; Yao, Wanzhen1
关键词Airway Inflammation Chronic Persistent Asthma Correlation Hydrogen Sulfide Lung Function
刊名RESPIROLOGY
2014-11-01
DOI10.1111/resp.12372
19期:8页:1165-1169
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
资助者National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders ; National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders
研究领域[WOS]Respiratory System
关键词[WOS]INDUCED SPUTUM ; NEUTROPHILIC INFLAMMATION ; INHALED CORTICOSTEROIDS ; SODIUM SULFIDE ; HYPERRESPONSIVENESS ; IDENTIFICATION ; HEALTHY ; DISEASE ; GAS
英文摘要

Background and objectiveEndogenous hydrogen sulfide (H2S) may be a biomarker of asthma severity and activity. However, the relationship between exhaled H2S and airway inflammation phenotypes in asthma remains unclear. This study examined associations between endogenous H2S and chronic airway inflammatory phenotypes in patients with chronic persistent asthma.

MethodsOne hundred forty-eight patients (47 males, 101 females, 47.415.3 years old) with chronic persistent asthma were enrolled. Induced sputum cells were examined, and patients were grouped according to sputum inflammatory cell composition. Baseline demographics, Asthma Control Test (ACT) scores, spirometry data and H2S levels in exhaled air and plasma were obtained for all patients.

ResultsThe eosinophilic, neutrophilic, mixed granulocytic and paucigranulocytic inflammation groups included 57 (38.5%), 28 (18.9%), 23 (15.5%) and 40 (27%) subjects, respectively. The paucigranulocytic group had the best lung function, and patients with eosinophilic inflammation had lower ACT scores than patients with paucigranulocytic findings. In the eosinophilic group, lower exhaled H2S were found and exhaled H2S levels were negatively correlated with sputum eosinophil counts (R=-0.428, P<0.01). Exhaled H2S levels were positively correlated with percent of predicted forced expiratory volume in 1s (R=0.567, P<0.01) and ACT score (R=0.519, P<0.01).

ConclusionsExhaled H2S may be a useful marker of airway inflammation in asthma.

The aim of this study was to examine the correlation between endogenous H2S and chronic airway inflammation in patients with chronic persistent asthma. Patients were grouped using induced sputum as predominantly eosinophilic, neutrophilic, mixed granulocytic or paucigranulocytic. Exhaled H2S may be a useful marker of airway inflammation in asthma.

语种英语
所属项目编号81170012 ; 81370141 ; 201002008 ; 2013HXFB05
资助者National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders ; National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders
WOS记录号WOS:000343797700010
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57287
专题北京大学第三临床医学院_呼吸科
作者单位1.Peking Univ, Dept Resp Dis, Hosp 3, Beijing 100191, Peoples R China
2.Beijing Tongren Hosp, Dept Resp Dis, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jing,Wang, Xinmao,Chen, Yahong,et al. Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma[J]. RESPIROLOGY,2014,19(8):1165-1169.
APA Zhang, Jing,Wang, Xinmao,Chen, Yahong,&Yao, Wanzhen.(2014).Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma.RESPIROLOGY,19(8),1165-1169.
MLA Zhang, Jing,et al."Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma".RESPIROLOGY 19.8(2014):1165-1169.
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