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学科主题临床医学
Quantitative assessment and correlation analysis of cerebral microbleed distribution and leukoaraiosis in stroke outpatients
Yang, Qiong1; Yang, Yan1; Li, Chengyu1; Li, Jian1; Liu, Xiangyi1; Wang, Aonan1; Zhao, Jialing1; Wang, Mengyuan1; Zeng, Xiangzhu2; Fan, Dongsheng1
关键词Cerebral Amyloid Angiopathy Cerebral Microbleeds Distribution Gradient-recalled Echo Leukoaraiosis
刊名NEUROLOGICAL RESEARCH
2015-05-01
DOI10.1179/1743132815Y.0000000027
37期:5页:403-409
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
资助者Science and Technology Program of Beijing, China ; Science and Technology Program of Beijing, China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RISK-FACTORS ; ISCHEMIC-STROKE ; AMYLOID ANGIOPATHY ; COGNITIVE FUNCTION ; ROTTERDAM SCAN ; PREVALENCE ; DEMENTIA ; ASSOCIATION ; LESIONS
英文摘要

Objective: Cerebral microbleeds (CMBs) are bleeding events associated with cerebral small vessel disease (SVD). Strictly lobar CMBs and strictly deep CMBs are likely caused by cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy, respectively. Leukoaraiosis (LA) reflects an ischaemic change in SVD, and LA severity has been correlated with CMBs. However, whether different locations (aetiologies) of CMBs correlate with LA is unknown.

Methods: Patients receiving brain MRI and T2*-weighted gradient-recalled echo scans in a stroke outpatient department were screened for CMBs. The MRI results of the patients with CMBs were sent to investigators for further review and were evaluated using the Microbleed Anatomical Rating Scale. Cerebral microbleed severity was graded using a numerical scale. Leukoaraiosis severity was assessed using the Fazekas scale.

Results: Cerebral microbleeds were observed in 14.6% of the 1289 screened patients. The CMB incidence increased with age (in years, <50: 1.3%; 50-59: 10.7%; 60-69: 17.6% and >= 70: 23.6%; P=0.000). The CMB locations were distributed as follows: 23.4% strictly lobar, 12.2% strictly deep, 6.4% strictly infratentorial and 58.0% mixed. Cerebral microbleed severity correlated with the total Fazekas scale score. The numbers of lobar, deep and infratentorial CMBs correlated with the total Fazekas scale score. The mixed CMB group displayed a significantly higher Fazekas scale score than the strictly lobar CMB group (P=0.000).

Discussion: Cerebral microbleed incidence increased with age. Mixed CMB type displayed the highest incidence. The severity and number of CMBs at any location correlated with LA severity. These results suggested interactions between hypertension and CAA during LA progression.

语种英语
所属项目编号D141100000114005
资助者Science and Technology Program of Beijing, China ; Science and Technology Program of Beijing, China
WOS记录号WOS:000354811200007
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57288
专题北京大学第三临床医学院_神经内科
作者单位1.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Qiong,Yang, Yan,Li, Chengyu,et al. Quantitative assessment and correlation analysis of cerebral microbleed distribution and leukoaraiosis in stroke outpatients[J]. NEUROLOGICAL RESEARCH,2015,37(5):403-409.
APA Yang, Qiong.,Yang, Yan.,Li, Chengyu.,Li, Jian.,Liu, Xiangyi.,...&Fan, Dongsheng.(2015).Quantitative assessment and correlation analysis of cerebral microbleed distribution and leukoaraiosis in stroke outpatients.NEUROLOGICAL RESEARCH,37(5),403-409.
MLA Yang, Qiong,et al."Quantitative assessment and correlation analysis of cerebral microbleed distribution and leukoaraiosis in stroke outpatients".NEUROLOGICAL RESEARCH 37.5(2015):403-409.
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