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学科主题: 药学
题名:
I-2- or NBS-Catalyzed Highly Efficient alpha-Hydroxylation of Ketones with Dimethyl Sulfoxide
作者: Liang, Yu-Feng1; Wu, Kai1; Song, Song1; Li, Xinyao1; Huang, Xiaoqiang1; Jiao, Ning1,2
刊名: ORGANIC LETTERS
发表日期: 2015-02-20
DOI: 10.1021/ol5037387
卷: 17, 期:4, 页:876-879
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: C-H HYDROXYLATION ; ASYMMETRIC TRANSFER HYDROGENATION ; ALKOXYSULFONIUM IONS ; METHYL KETONES ; FACILE ACCESS ; OXIDATION ; BONDS ; FUNCTIONALIZATION ; OXYGENATION ; ALCOHOLS
英文摘要:

An efficient method for the direct preparation of high synthetic valuable a-hydroxycarbonyls is described. The simple and readily available I-2 or NBS was used as catalyst. DMSO acts as the oxidant, oxygen source, and solvent. A diverse range of tertiary Csp(3)-H bonds as well as more challenging secondary Csp(3)-H bonds could be hydroxylated in this transformation. The reaction is mild, less toxic and easy to perform.

语种: 英语
所属项目编号: 2015CB856600 ; 21325206 ; 21172006
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
WOS记录号: WOS:000349942600029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57290
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200062, Peoples R China

Recommended Citation:
Liang, Yu-Feng,Wu, Kai,Song, Song,et al. I-2- or NBS-Catalyzed Highly Efficient alpha-Hydroxylation of Ketones with Dimethyl Sulfoxide[J]. ORGANIC LETTERS,2015,17(4):876-879.
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