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I-2- or NBS-Catalyzed Highly Efficient alpha-Hydroxylation of Ketones with Dimethyl Sulfoxide
Liang, Yu-Feng1; Wu, Kai1; Song, Song1; Li, Xinyao1; Huang, Xiaoqiang1; Jiao, Ning1,2
刊名ORGANIC LETTERS
2015-02-20
DOI10.1021/ol5037387
17期:4页:876-879
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]C-H HYDROXYLATION ; ASYMMETRIC TRANSFER HYDROGENATION ; ALKOXYSULFONIUM IONS ; METHYL KETONES ; FACILE ACCESS ; OXIDATION ; BONDS ; FUNCTIONALIZATION ; OXYGENATION ; ALCOHOLS
英文摘要

An efficient method for the direct preparation of high synthetic valuable a-hydroxycarbonyls is described. The simple and readily available I-2 or NBS was used as catalyst. DMSO acts as the oxidant, oxygen source, and solvent. A diverse range of tertiary Csp(3)-H bonds as well as more challenging secondary Csp(3)-H bonds could be hydroxylated in this transformation. The reaction is mild, less toxic and easy to perform.

语种英语
WOS记录号WOS:000349942600029
项目编号2015CB856600 ; 21325206 ; 21172006
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57290
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200062, Peoples R China
推荐引用方式
GB/T 7714
Liang, Yu-Feng,Wu, Kai,Song, Song,et al. I-2- or NBS-Catalyzed Highly Efficient alpha-Hydroxylation of Ketones with Dimethyl Sulfoxide[J]. ORGANIC LETTERS,2015,17(4):876-879.
APA Liang, Yu-Feng,Wu, Kai,Song, Song,Li, Xinyao,Huang, Xiaoqiang,&Jiao, Ning.(2015).I-2- or NBS-Catalyzed Highly Efficient alpha-Hydroxylation of Ketones with Dimethyl Sulfoxide.ORGANIC LETTERS,17(4),876-879.
MLA Liang, Yu-Feng,et al."I-2- or NBS-Catalyzed Highly Efficient alpha-Hydroxylation of Ketones with Dimethyl Sulfoxide".ORGANIC LETTERS 17.4(2015):876-879.
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