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Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis
Wang, Feng1; Xia, Weiwei1; Liu, Feng1; Li, Ji1; Wang, Guang2; Gu, Jun1
关键词Atherosclerosis 25-hydroxycholesterol Retinoic Inducible Gene i Interferon Regulatory Factor 1 Inflammation
刊名CARDIOVASCULAR RESEARCH
2012
DOI10.1093/cvr/cvr260
93期:1页:190-199
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National Basic Research Program, China ; National Basic Research Program, China
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]NF-KAPPA-B ; HUMAN ENDOTHELIAL-CELLS ; SMOOTH-MUSCLE-CELLS ; RIG-I ; VASCULAR ENDOTHELIUM ; ADAPTER PROTEIN ; TNF-ALPHA ; EXPRESSION ; MACROPHAGES ; ACTIVATION
英文摘要

Aims In this study, the role of retinoic inducible gene I (RIG-I)-mediated signalling in the inflammation of atherosclerosis was investigated to explain the pathology of atherosclerosis.

Methods and results Human and mouse primary cells were exposed to 25-hydroxycholesterol followed by examination of gene expression and activation of the signal pathway with biochemical and molecular biological techniques. A mouse atherosclerotic model was also used. We found that RIG-I was induced inmacrophages and endothelium by 25-hydroxycholesterol. Interferon regulatory factor 1 is a key transcription factor for the induction of RIG-I by 25-hydroxycholesterol. The induction of interleukin-8 and growth-regulated protein a, the mouse interleukin-8 homologue, by 25-hydroxycholesterol is mediated by RIG-I signalling. RIG-I transduces the signal to downstream molecules, mitochondrial antiviral-signalling protein, transforming growth factor-beta-activated kinase 1, and mitogen-activated protein kinase, leading to the activation of nuclear factor kappa B, activator protein-1, and nuclear factor interleukin-6, all of which are required for the expression of interleukin-8. Finally, we observed that RIG-I is highly expressed in atherosclerotic lesions.

Conclusion Our data demonstrate that RIG-I signalling mediates atherosclerotic inflammation. Targeting RIG-I signalling should provide a way to inhibit atherosclerotic inflammation, which holds potential for the therapy of atherosclerosis.

语种英语
所属项目编号2010CB911801 ; 2011CB503904
资助者National Basic Research Program, China ; National Basic Research Program, China
WOS记录号WOS:000298381600024
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57294
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, State Key Lab Prot & Plant Gene Res, Coll Life Sci, Beijing 100871, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Feng,Xia, Weiwei,Liu, Feng,et al. Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis[J]. CARDIOVASCULAR RESEARCH,2012,93(1):190-199.
APA Wang, Feng,Xia, Weiwei,Liu, Feng,Li, Ji,Wang, Guang,&Gu, Jun.(2012).Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis.CARDIOVASCULAR RESEARCH,93(1),190-199.
MLA Wang, Feng,et al."Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis".CARDIOVASCULAR RESEARCH 93.1(2012):190-199.
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