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学科主题: 临床医学
题名:
Lipoprotein p37 from Mycoplasma hyorhinis inhibiting mammalian cell adhesion
作者: Liu, WB; Zhang, JZ; Jiang, BH; Ren, TT; Gong, MM; Meng, L; Shou, CC
关键词: cell adhesion ; Golgi apparatus ; Mycoplasma hyorhinis ; p37 protein
刊名: JOURNAL OF BIOMEDICAL SCIENCE
发表日期: 2006-05-01
DOI: 10.1007/s11373-005-9045-7
卷: 13, 期:3, 页:323-331
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: RNA-POLYMERASE-II ; REAL-TIME PCR ; MALIGNANT-TRANSFORMATION ; ENDOTHELIAL-CELLS ; TERMINAL DOMAINS ; PROTEIN ; INVASIVENESS ; INFECTIONS ; ACTIVATION ; EXPRESSION
英文摘要:

p37 protein is a membrane lipoprotein of Mycoplasma hyorhinis, and our previous work showed that there was high ratio of M. hyorhinis infection in human gastric carcinoma. To investigate the possible functions of p37 in cancer development, the nucleotide sequence of p37 gene was modified and expressed well in transfected cells. We found that p37 localized at the Golgi apparatus and could be secreted out of the cell. Human gastric cancer cells AGS, after being transfected with the p37 gene, were smaller, more spherical and easy to detach from each other. Their adhesion to matrix was also diminished and cytoskeleton in these stable p37 AGS cell was rearranged and transcription co-factor beta-actin was transferred to nucleolus with down-regulation of ICAM-1 and integrin beta 1. These findings will be helpful for us to elucidate the effects of p37 on eukaryotic cells as well as to better understand the potential relationship between cancer and mycoplasma infection.

语种: 英语
WOS记录号: WOS:000237502100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57295
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing 100034, Peoples R China
2.Beijing Inst Canc Res, Beijing 100034, Peoples R China

Recommended Citation:
Liu, WB,Zhang, JZ,Jiang, BH,et al. Lipoprotein p37 from Mycoplasma hyorhinis inhibiting mammalian cell adhesion[J]. JOURNAL OF BIOMEDICAL SCIENCE,2006,13(3):323-331.
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