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学科主题: 医学信息学
题名:
LncRNADisease: a database for long-non-coding RNA-associated diseases
作者: Chen, Geng1,2,3; Wang, Ziyun2; Wang, Dongqing2; Qiu, Chengxiang2; Liu, Mingxi4; Chen, Xing4; Zhang, Qipeng2; Yan, Guiying4; Cui, Qinghua1,2,3
刊名: NUCLEIC ACIDS RESEARCH
发表日期: 2013
DOI: 10.1093/nar/gks1099
卷: 41, 期:D1, 页:D983-D986
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: NONCODING RNAS ; HUMAN MICRORNA ; EXPRESSION ; CANCER ; ANRIL
英文摘要:

In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjm u.edu.cn/Incrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs′ roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA-disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA-disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA-disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA-disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database.

语种: 英语
所属项目编号: 2012CB517500 ; 31000585 ; 11021161
项目资助者: National Basic Research program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000312893300139
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57298
Appears in Collections:基础医学院_医学信息学系_期刊论文

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作者单位: 1.Peking Univ, Inst Syst Biomed, Beijing 100190, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100190, Peoples R China
3.Peking Univ, MOE Key Lab Cardiovasc Sci, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China

Recommended Citation:
Chen, Geng,Wang, Ziyun,Wang, Dongqing,et al. LncRNADisease: a database for long-non-coding RNA-associated diseases[J]. NUCLEIC ACIDS RESEARCH,2013,41(D1):D983-D986.
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