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学科主题医学信息学
LncRNADisease: a database for long-non-coding RNA-associated diseases
Chen, Geng1,2,3; Wang, Ziyun2; Wang, Dongqing2; Qiu, Chengxiang2; Liu, Mingxi4; Chen, Xing4; Zhang, Qipeng2; Yan, Guiying4; Cui, Qinghua1,2,3
刊名NUCLEIC ACIDS RESEARCH
2013
DOI10.1093/nar/gks1099
41期:D1页:D983-D986
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]NONCODING RNAS ; HUMAN MICRORNA ; EXPRESSION ; CANCER ; ANRIL
英文摘要

In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjm u.edu.cn/Incrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs′ roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA-disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA-disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA-disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA-disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database.

语种英语
WOS记录号WOS:000312893300139
项目编号2012CB517500 ; 31000585 ; 11021161
资助机构National Basic Research program of China ; National Natural Science Foundation of China
引用统计
被引频次:295[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57298
专题北京大学基础医学院_医学信息学系
北京大学基础医学院
作者单位1.Peking Univ, Inst Syst Biomed, Beijing 100190, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100190, Peoples R China
3.Peking Univ, MOE Key Lab Cardiovasc Sci, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
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GB/T 7714
Chen, Geng,Wang, Ziyun,Wang, Dongqing,et al. LncRNADisease: a database for long-non-coding RNA-associated diseases[J]. NUCLEIC ACIDS RESEARCH,2013,41(D1):D983-D986.
APA Chen, Geng.,Wang, Ziyun.,Wang, Dongqing.,Qiu, Chengxiang.,Liu, Mingxi.,...&Cui, Qinghua.(2013).LncRNADisease: a database for long-non-coding RNA-associated diseases.NUCLEIC ACIDS RESEARCH,41(D1),D983-D986.
MLA Chen, Geng,et al."LncRNADisease: a database for long-non-coding RNA-associated diseases".NUCLEIC ACIDS RESEARCH 41.D1(2013):D983-D986.
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