IR@PKUHSC  > 北京大学第三临床医学院  > 运动医学研究所
学科主题临床医学
Meniscus Transplantation Using Treated Xenogeneic Meniscal Tissue: Viability and Chondroprotection Study in Rabbits
Jiang, Dong; Zhao, Li-Heng; Tian, Ming; Zhang, Ji-Ying; Yu, Jia-Kuo
刊名ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
2012-08-01
DOI10.1016/j.arthro.2012.01.001
28期:8页:1147-1159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics ; Surgery
资助者National Natural Science Foundation ; National Natural Science Foundation
研究领域[WOS]Orthopedics ; Surgery
关键词[WOS]ALLOGRAFT TRANSPLANTATION ; ARTICULAR-CARTILAGE ; FOLLOW-UP ; MECHANICAL-PROPERTIES ; KNEE ; MENISCECTOMY ; REPLACEMENT ; DOGS ; 2-YEAR ; DEGENERATION
英文摘要

Purpose: This was a preliminary study performed in vivo to evaluate the viability and the chondroprotective effects of irradiated deep-frozen xenogeneic meniscal tissue as a novel substitute for meniscus transplantation. Methods: Medial meniscectomies were performed on the right knees of 48 New Zealand white rabbits. The inner one-third of pig meniscus was harvested and then irradiated and deeply frozen. The treated xenogeneic meniscal tissues were then transplanted to 24 right knees (Xeno group), whereas 24 other knees received meniscus allograft transplantations (Allo group). The left knees of the Xeno group and Allo group received meniscectomies (Meni group) and sham operations (Sham group), respectively. The rabbits were killed at weeks 6, 12, and 24 postoperatively. The newly formed structure of the implanted tissue and cartilage of the medial compartment of each group was assessed by gross and semiquantitative histologic analysis. Results: After 24 weeks, the implanted xenogeneic meniscal tissue completely healed to the synovium and formed meniscus-like tissue. The chondrocyte-like cell infiltrated into the tissue with extracellular matrix including type II collagen and proteoglycans. The Xeno group showed significantly less cartilage degeneration than that of the Meni group in the medial tibial plateau at week 24 (P < .05). No significant difference was found between the Xeno group and the Allo group except for the meniscus-covered regions at week 24. From week 12 to week 24, almost no advanced cartilage degeneration was found in weight-bearing regions of the medial tibial plateau of the Xeno group. Conclusions: The treated xenogeneic meniscal tissue healed to the synovium with tissue regeneration and slowed down articular cartilage degeneration in the short-term. The chondroprotection of xenograft transplantation was similar to that of allograft transplantation. Clinical Relevance: The treated xenogeneic meniscal tissue showed the potential for viability and slowed cartilage degeneration, but more studies are required for application in humans in the future.

语种英语
资助者National Natural Science Foundation ; National Natural Science Foundation
WOS记录号WOS:000306897900018
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57300
专题北京大学第三临床医学院_运动医学研究所
作者单位Peking Univ, Third Hosp, Inst Sports Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Dong,Zhao, Li-Heng,Tian, Ming,et al. Meniscus Transplantation Using Treated Xenogeneic Meniscal Tissue: Viability and Chondroprotection Study in Rabbits[J]. ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY,2012,28(8):1147-1159.
APA Jiang, Dong,Zhao, Li-Heng,Tian, Ming,Zhang, Ji-Ying,&Yu, Jia-Kuo.(2012).Meniscus Transplantation Using Treated Xenogeneic Meniscal Tissue: Viability and Chondroprotection Study in Rabbits.ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY,28(8),1147-1159.
MLA Jiang, Dong,et al."Meniscus Transplantation Using Treated Xenogeneic Meniscal Tissue: Viability and Chondroprotection Study in Rabbits".ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY 28.8(2012):1147-1159.
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